Diethyl 2-(3-trifluoromethylphenyl)malonate CAS 1997-28-0
| CAS No. | 1997-28-0 |
| Molecular Formula | C14H15F3O4 |
| Molecular Weight | 304.26 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Diethyl 2-(3-trifluoromethylphenyl)malonate.
CATO supplies Diethyl 2-(3-trifluoromethylphenyl)malonate (CAS 1997-28-0), a certified reference material (molecular formula C14H15F3O4, MW 304.26 g/mol) for analytical method development and quality control.
Structurally, Diethyl 2-(3-trifluoromethylphenyl)malonate (C14H15F3O4) contains a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. The molecule exhibits a degree of unsaturation (DBE) of 6.0, corresponding to approximately 6 ring(s) or double-bond equivalent(s). With a molecular weight of 304.26 g/mol, it falls into the moderately-high-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), Diethyl 2-(3-trifluoromethylphenyl)malonate meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C14H15F3O4 |
| Molecular Weight | 304.26 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | F-containing |
Related Diethyl Standards
- Diethyl ((2,4-dimethoxyphenyl)(hydroxy)methyl)phosphonate (CAS 62002-63-5)
- Diethyl ((2,5-dimethoxyphenyl)(hydroxy)methyl)phosphonate (CAS 430471-09-3)
- Diethyl 1,4-Dihydroxynaphthalene-2,3-dicarboxylate (CAS 59883-07-7)
- 1,3-Diethyl 2-{[(1,3-benzoxazol-5-yl)amino]methylidene}propanedioate (CAS 177492-53-4)
- Diethyl benzhydrylphosphonate (CAS 27329-60-8)
- Diethyl 2-benzyl-3-oxosuccinate (CAS 54670-87-0)
- Diethyl 2-(2,4-dichlorophenyl)malonate (CAS 111544-93-5)
- 1,3-diethyl 2-(3,5-dichlorophenyl)propanedioate (CAS 1186194-50-2)
Recommended Standards
- 5-((4-Fluorophenyl)thio)-1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carbaldehyde (CAS 321848-46-8)
- Vicine (CAS 152-93-2)
- 3-(Benzo[d]oxazol-2-yl)-7-hydroxy-2-oxo-2H-chromene-4-carbonitrile (CAS 90146-01-3)
- 3-(4-(3-(Trifluoromethyl)phenoxy)phenyl)-1H-pyrazole (CAS 1019007-78-3)
- 7-Bromo-2,4-bis(methylthio)imidazo[2,1-f][1,2,4]triazine (CAS 1062135-87-8)
- 3-Ethoxy-5-(tetramethyl-1,3,2-dioxaborolan-2-yl)benzoic acid (CAS 1801514-64-6)
- 5-[2-(furan-2-yl)ethenyl]-1,3,4-thiadiazol-2-amine (CAS 299935-03-8)
- (R)-Ethyl 4-benzylmorpholine-3-carboxylate (CAS 106910-85-4)
- 1-Phenylpiperidine-2,4-dione (CAS 99539-86-3)
- N-Butyl-3-nitrobenzamide (CAS 70001-47-7)
- 2-methyl-1,6-naphthyridine-3-carboxylic acid (CAS 387350-63-2)
- trans-2-[2-(2-Chlorophenyl)-2-oxoethyl]-cyclopentane-1-carboxylic acid (CAS 733740-68-6)
- Momelotinib impurity 14 (CAS 2107522-02-9)
- Semaglutide impurity 103 (CAS 1446013-07-5)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com