4-(Chloromethyl)-2-(methylthio)pyrimidine hydrochloride CAS 1998216-04-8
| CAS No. | 1998216-04-8 |
| Molecular Formula | C6H7ClN2S |
| Molecular Weight | N/A |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 4-(Chloromethyl)-2-(methylthio)pyrimidine hydrochloride.
CATO supplies 4-(Chloromethyl)-2-(methylthio)pyrimidine hydrochloride (CAS 1998216-04-8), a certified reference material (molecular formula C6H7ClN2SHCl, MW 211.10 g/mol) for analytical method development and quality control.
The molecular framework of 4-(Chloromethyl)-2-(methylthio)pyrimidine hydrochloride (C6H7ClN2SHCl) is characterized by a nitrile group, sulfur-containing functionality, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C6H7ClN2S HCl |
| Molecular Weight | 211.10 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1996 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
Related Chloromethyl Standards
- 7-(Chloromethyl)-3-methyl-5H-thiazolo[3,2-a]pyrimidin-5-one (CAS 100003-81-4)
- 7-(Chloromethyl)-2,3-dimethyl-5H-thiazolo[3,2-a]pyrimidin-5-one (CAS 100003-82-5)
- 7-(Chloromethyl)-3-(4-chlorophenyl)-5H-thiazolo[3,2-a]pyrimidin-5-one (CAS 100003-85-8)
- chloromethyl 2-ethoxy-2-methylpropanoate (CAS 1000296-74-1)
- 5-(chloromethyl)-N-(4-methylbenzyl)-1,3,4-thiadiazole-2-carboxamide (CAS 1000932-24-0)
- 5-(Chloromethyl)-7-ethoxy-2-(trifluoromethyl)-[1,2,4]triazolo[1,5-a]pyrimidine (CAS 1000932-47-7)
- 5-(chloromethyl)-N-(4-fluorobenzyl)-1,3,4-thiadiazole-2-carboxamide (CAS 1000932-60-4)
- 2-(Chloromethyl)-5,6-diphenylfuro[2,3-d]pyrimidin-4-amine (CAS 1000933-67-4)
Recommended Standards
- 2-((4-Methoxybenzyl)amino)ethanol (CAS 64834-63-5)
- 2-(Difluoromethyl)-6-iodo-5-nitropyridine-3-sulfonyl chloride (CAS 1805423-24-8)
- Methoxy-d (CAS 71444-46-7)
- 4-(4-Chlorophenyl)-5-(2,2-dimethoxyethyl)-2,4-dihydro-3H-1,2,4-triazole-3-thione (CAS 477851-06-2)
- 3-Isobutoxyaniline (CAS 37532-43-7)
- n-(Propan-2-yl)-5,6,7,8-tetrahydroquinolin-8-amine (CAS 1427380-60-6)
- 2-chloro-3-(1,3-dioxolan-2-yl)-6-fluorobenzonitrile (CAS 1795362-29-6)
- Propafenone EP Impurity E (CAS 165279-79-8)
- (3S)-3-Mercapto-1-pyrrolidinecarboxylic Acid (4-Nitrophenyl)methyl Ester (CAS 87657-41-8)
- Neuropeptide FF (CAS 99566-27-5)
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