4-(Bromomethyl)-3-nitropyridine hydrobromide CAS 19993-59-0
| CAS No. | 19993-59-0 |
| Molecular Formula | C6H5BrN2O2 |
| Molecular Weight | N/A |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of 4-(Bromomethyl)-3-nitropyridine hydrobromide (C6H5BrN2O2HBr) is characterized by an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, bromine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
4-(Bromomethyl)-3-nitropyridine hydrobromide (CAS 19993-59-0), molecular formula C6H5BrN2O2HBr and molecular weight 297.93 g/mol, is a CATO reference standard with documented purity and traceability.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C6H5BrN2O2 HBr |
| Molecular Weight | 297.93 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1962 |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 2 |
Related Bromomethyl Standards
- 5-(Bromomethyl)-2-methyl-4-(trifluoromethyl)thiazole (CAS 1000339-73-0)
- 2-Bromomethyl-5-chloro-1,3-dinitrobenzene (CAS 1000341-01-4)
- 2-(Bromomethyl)-2-butylhexanoic Acid (CAS 100048-86-0)
- 2-(Bromomethyl)-5-(trifluoromethyl)pyridine (CAS 1000773-62-5)
- 4-(bromomethyl)-2-methylbenzonitrile (CAS 1001055-64-6)
- 2-(Bromomethyl)pyridin-3-ol hydrochloride (CAS 1001096-21-4)
- 2-(Bromomethyl)-6-fluoropyridine (CAS 100202-78-6)
- 2-(bromomethyl)-1-oxaspiro[4.4]nonane (CAS 100238-92-4)
Recommended Standards
- 2-(Diphenylmethylene)-1H-indene-1,3(2H)-dione (CAS 13248-12-9)
- 2-(1H-indol-3-yl)-N-(3-methoxybenzyl)ethanamine 435342-06-6 [2-(1 H-indol-3-yl)-ethyl]-(3-methoxy-benzyl)-amine (CAS 435342-06-6)
- (4-Fluoro-2-(pyrrolidin-1-ylmethyl)phenyl)boronic acid (CAS 1704063-81-9)
- Apremilast Impurity 66 (CAS 587-48-4)
- (R)-N-(4-chlorobenzylidene)-2-methylpropane-2-sulfinamide (CAS 336105-23-8)
- 2-Carboxy-5-methoxypyridine 1-oxide (CAS 672957-93-6)
- 1-[(2-Amino-1,3-thiazol-4-yl)methyl]piperidin-4-ol dihydrochloride (CAS 1426290-49-4)
- (2-([2-(4-Chlorophenyl)-1h-indol-3-yl]thio)ethyl)amine (CAS 865546-54-9)
- 9,10-Di(naphthalen-2-yl)-2-phenylanthracene (CAS 865435-20-7)
- Semaglutide impurity 203 (CAS CATO-C4X-2226203)
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