5-(4-Chloro-2-fluorophenyl)oxazole CAS 2020663-34-5
| CAS No. | 2020663-34-5 |
| Molecular Formula | C9H5ClFNO |
| Molecular Weight | 197.59 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
5-(4-Chloro-2-fluorophenyl)oxazole (CAS 2020663-34-5) is a high-purity analytical reference standard with the molecular formula C9H5ClFNO and a molecular weight of 197.59 g/mol.
The molecular framework of 5-(4-Chloro-2-fluorophenyl)oxazole (C9H5ClFNO) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 5-(4-Chloro-2-fluorophenyl)oxazole meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C9H5ClFNO |
| Molecular Weight | 197.59 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1996 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related Chloro Standards
- 5-Chloro-8-fluoroquinolin-4(1H)-one (CAS 1019016-37-5)
- 6-Chloro-8-fluoroquinolin-4-ol (CAS 1019016-45-5)
- 7-Chloro-8-fluoroquinolin-4(1H)-one (CAS 1019016-52-4)
- 7-Chloro-6-fluoroquinolin-4(1H)-one (CAS 106024-91-3)
- 2-Chloro-5-(4-fluorophenyl)oxazole (CAS 1060816-27-4)
- 6-Chloro-7-fluoroquinolin-4(1H)-one (CAS 1065092-30-9)
- 8-Chloro-5-fluoroquinolin-4(1H)-one (CAS 1065092-32-1)
- 8-Chloro-7-fluoroquinolin-4(1H)-one (CAS 1065092-33-2)
Recommended Standards
- 5-(2-Chloro-6-fluorophenyl)oxazole (CAS 2021428-58-8)
- 5-(4-Chloro-3-ffluorophenyl)-1,3-oxazole (CAS 2002638-39-1)
- 5-(2-Chloro-4-fluorophenyl)-oxazole (CAS 2004517-65-9)
- 5-Fluoro-1H-indole-2-carbonyl chloride (CAS 79112-09-7)
- 2-(2-Chloro-4-cyano-6-(difluoromethyl)pyridin-3-yl)acetic acid (CAS 1805260-93-8)
- 2-(2-(2-Bromobenzyl)thiazol-4-yl)acetic acid (CAS 1053656-88-4)
- 5-Bromo-2-ethoxy-4-methylpyridin-3-amine (CAS 1373233-15-8)
- 2-[1-(Cyclohexylmethyl)-3-oxo-2-piperazinyl]acetic acid (CAS 1033600-29-1)
- 5-Bromo-3-iodo-2-methylbenzoic acid, 97% (CAS 1379364-28-9)
- 4-Cyano-6-(difluoromethyl)-2-iodo-3-methylpyridine (CAS 1804730-04-8)
- 3-(4-Fluorophenyl)-1-methyl-1h-pyrazole-4-carbaldehyde (CAS 689250-53-1)
- 5-Chloro-2-(prop-2-yn-1-yl)pyridine (CAS 1260672-19-2)
- 1-[2-chloro-4-(4-fluorophenoxy)phenyl]ethan-1-one (CAS 1021187-74-5)
- Des-Ser32-Tirzepatide (CAS CATO-CPTD788942)
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