1-(2,6-Difluoro-4-nitrophenyl)cyclopropane-1-carboxylic acid CAS 2021938-33-8
| CAS No. | 2021938-33-8 |
| Molecular Formula | C10H7F2NO4 |
| Molecular Weight | 243.16 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 1-(2,6-Difluoro-4-nitrophenyl)cyclopropane-1-carboxylic acid.
CATO supplies 1-(2,6-Difluoro-4-nitrophenyl)cyclopropane-1-carboxylic acid (CAS 2021938-33-8), a certified reference material (molecular formula C10H7F2NO4, MW 243.16 g/mol) for analytical method development and quality control.
The molecular framework of 1-(2,6-Difluoro-4-nitrophenyl)cyclopropane-1-carboxylic acid (C10H7F2NO4) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 1-(2,6-Difluoro-4-nitrophenyl)cyclopropane-1-carboxylic acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C10H7F2NO4 |
| Molecular Weight | 243.16 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1996 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Difluoro Standards
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- 9,9-Difluoro-3-azaspiro[5.5]Undecane (CAS 1781297-83-3)
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- 3-Chloro-2-methyl-4-nitroaniline (CAS 64863-10-1)
- 6-(trifluoromethyl)imidazo[2,1-b]thiazole (CAS 109113-98-6)
- 2-([(2,3-Dimethoxyphenyl)methyl]-sulfanyl)ethan-1-amine (CAS 1147093-47-7)
- Nepafenac Impurity 12 (CAS 98190-48-8)
- Isoamyl Formate (CAS 110-45-2)
- 3-Methyl-N-(m-tolyl)benzamide (CAS 53205-69-9)
- tert-Butyl 5-aminospiro[indoline-3,4'-piperidine]-1'-carboxylate (CAS 1260897-95-7)
- T-Peptide (CAS 2022956-62-1)
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