3-(Difluoromethoxy)thiophene-2-carboxylic acid CAS 202400-94-0
| CAS No. | 202400-94-0 |
| Molecular Formula | C6H4F2O3S |
| Molecular Weight | 194.16 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
3-(Difluoromethoxy)thiophene-2-carboxylic acid (CAS 202400-94-0), molecular formula C6H4F2O3S and molecular weight 194.16 g/mol, is a CATO reference standard with documented purity and traceability.
Structurally, 3-(Difluoromethoxy)thiophene-2-carboxylic acid (C6H4F2O3S) contains a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. The molecule exhibits a degree of unsaturation (DBE) of 4.0, corresponding to approximately 4 ring(s) or double-bond equivalent(s). With a molecular weight of 194.16 g/mol, it falls into the medium-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures 3-(Difluoromethoxy)thiophene-2-carboxylic acid under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C6H4F2O3S |
| Molecular Weight | 194.16 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2014 |
| Halogen Content | F-containing |
| Sulfur Atoms | 1 |
Related Difluoromethoxy Standards
- 4-(Difluoromethoxy)thiophene-2-carboxylic acid (CAS 1521416-94-3)
- 5-Difluoromethoxy-2-fluorothiophenol (CAS 1803779-48-7)
- 2-Difluoromethoxy-3-fluorothiophenol (CAS 1803823-72-4)
- 2-Difluoromethoxy-6-fluorothiophenol (CAS 1803824-35-2)
- 3-Difluoromethoxy-2-fluorothiophenol (CAS 1803849-00-4)
- 4-Difluoromethoxy-2-fluorothiophenol (CAS 1804886-68-7)
- 4-Difluoromethoxy-3-fluorothiophenol (CAS 1806305-26-9)
- 3-Difluoromethoxy-5-fluorothiophenol (CAS 1806376-65-7)
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