4-Methyl-2-(trichloromethyl)quinoline CAS 203626-79-3
| CAS No. | 203626-79-3 |
| Molecular Formula | C11H8Cl3N |
| Molecular Weight | 260.55 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
4-Methyl-2-(trichloromethyl)quinoline (CAS 203626-79-3), molecular formula C11H8Cl3N and molecular weight 260.55 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 4-Methyl-2-(trichloromethyl)quinoline (C11H8Cl3N) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 4-Methyl-2-(trichloromethyl)quinoline meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C11H8Cl3N |
| Molecular Weight | 260.55 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2015 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Methyl Standards
- 1-Phenyl-3-(trichloromethyl)-1H-pyrazole (CAS 83959-41-5)
- [(Trichloromethyl)sulfonyl]benzene (CAS 42764-08-9)
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- 1-(Trichloromethyl)-4-(trifluoromethyl)benzene (CAS 13947-96-1)
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- 3-phenyl-5-(trichloromethyl)-1,2,4-oxadiazole (CAS 1208-05-5)
- 2-(Trichloromethyl)-3,4-dihydroquinazolin-4-one (CAS 5558-95-2)
- 3-(Trichloromethyl)quinoxalin-2-ol (CAS 73855-49-9)
Recommended Standards
- 2,7-Dichloro-3-(chloromethyl)-8-methylquinoline (CAS 948292-24-8)
- 6-Chloro-2,3-difluoro-4-(trifluoromethyl)benzoic acid (CAS 773869-48-0)
- 2,5-Dichloro-3-(chloromethyl)-8-methylquinoline (CAS 948292-13-5)
- 2-(4-Bromo-2-chlorophenyl)pyrrolidine (CAS 1157719-55-5)
- 2-[3-[2-(2,6-dioxo-3-piperidyl)-1-oxo-isoindolin-5-yl]prop-2-ynoxy]acetaldehyde (CAS 2619512-42-2)
- 2,3,4,6,7,11B-hexahydro-1H-pyrido[2,1-a]isoquinolin-2-ol (CAS 5911-71-7)
- 6-fluoronaphthalen-1-ol (CAS 804498-72-4)
- 3-(4-methylpiperazin-1-yl)propanal (CAS 1124345-71-6)
- 2-(4-Chlorophenoxy)-2,2-difluoro-1-(pyrrolidin-1-yl)ethan-1-one (CAS 250714-70-6)
- 1110502-30-1 JAK2 inhibitor 13 - Sulfonamide 13 (CAS 1110502-30-1)
- 2-(((6-Methylpyridin-2-yl)amino)methyl)phenol (CAS 104768-37-8)
- 2,2'-((2-(4-(carboxymethyl)piperazin-1-yl)ethyl)azanediyl)diacetic acid (CAS 136369-41-0)
- 2-((3-(4-Bromophenyl)-4-oxo-3,4,5,6,7,8-hexahydrobenzo[4,5]thieno[2,3-d]pyrimidin-2-yl)thio)-N,N-diethylacetamide (CAS 476484-21-6)
- Semaglutide Impurity 131 (CAS 2618647-80-4)
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