N-(4-((3-Ethynylphenyl)amino)-7-methoxyquinazolin-6-yl)piperazine-1-carboxamide CAS 2044706-75-2
| CAS No. | 2044706-75-2 |
| Molecular Formula | C22H22N6O2 |
| Molecular Weight | 402.45 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
N-(4-((3-Ethynylphenyl)amino)-7-methoxyquinazolin-6-yl)piperazine-1-carboxamide (C22H22N6O2) contains a steroid core, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
N-(4-((3-Ethynylphenyl)amino)-7-methoxyquinazolin-6-yl)piperazine-1-carboxamide (CAS 2044706-75-2), molecular formula C22H22N6O2 and molecular weight 402.45 g/mol, is a CATO reference standard with documented purity and traceability.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), N-(4-((3-Ethynylphenyl)amino)-7-methoxyquinazolin-6-yl)piperazine-1-carboxamide meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C22H22N6O2 |
| Molecular Weight | 402.45 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1997 |
| Nitrogen Atoms | 6 |
Related N Standards
- N-(4-Ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine (CAS 1029721-32-1)
- 2-((4-((3-ethynylphenyl)amino)-6-(2-methoxyethoxy)quinazolin-7-yl)oxy)ethyl acetate (CAS 183320-24-3)
- ((4-((4-Ethynylphenyl)ethynyl)phenyl)-ethynyl)triisopropylsilane (CAS 176977-37-0)
- 2,4,6-Tris(4-ethynylphenyl)-1,3,5-triazine (CAS 425629-22-7)
- 1,2-Bis(4-ethynylphenyl)-1,2-diphenylethene (CAS 1240785-42-5)
- N-(4-Ethynylphenyl)-7-methoxy-6-(piperidin-1-yloxy)quinazolin-4-amine (CAS 918499-39-5)
- N-(3-Ethynylphenyl)-4-morpholino-3-(trifluoromethyl)benzamide (CAS 2499499-13-5)
- N-(3-Ethynylphenyl)-7-(2-methoxyethoxy)-6-nitroquinazolin-4-amine (CAS 1637255-37-8)
Recommended Standards
- H-Gly-Gly-Lys-Ala-Ala-OH (H-3450.0050) (CAS 68171-99-3)
- Pyrene-PEG2-azide (CAS 2135330-58-2)
- 6-Amino-4-(4-(benzyloxy)-3-ethoxyphenyl)-3-methyl-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile (CAS 315244-98-5)
- Urapidil Impurity 89 (CAS CATO-C4X-192489)
- 1-(1-Ethyl-1H-benzo[d]imidazol-2-yl)piperidin-4-ol (CAS 1065483-90-0)
- 2-[5-(Methoxymethyl)-1,2,4-oxadiazol-3-yl]morpholine hydrochloride (CAS 1707710-32-4)
- (4-Bromo-2-fluorophenyl)(4-(pyrrolidin-1-ylmethyl)phenyl)methanone (CAS 898776-71-1)
- Erdafitinib Impurity 13 (CAS 1346244-83-4)
- 5-Isopropoxypyridin-2-amine (CAS 846549-59-5)
- Cis-2-methyl-5-phenyltetrahydrofuran (CAS 38300-02-6)
- 1,2-Dichloro-4-(difluoromethoxy)-3-methylbenzene (CAS 1803833-82-0)
- 2-((4-Ethyl-2-oxo-2H-chromen-7-yl)oxy)acetic acid (CAS 314742-22-8)
- Lemborexant Impurity 45 (CAS CATO-C4X-304245)
- Liraglutide Sodium Salt (CAS 204656-20-2（free base）)
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