Amifostine CAS 20537-88-6

Description

The occurrence of Amifostine is closely related to an amide group, a sulfone group, a phosphonate group, a carboxylic acid group, a hydroxyl group, an ether linkage in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.

Amifostine (CAS 20537-88-6), molecular formula C5H15N2O3PS and molecular weight 214.22 g/mol, is a CATO reference standard with documented purity and traceability.

The molecular framework of Amifostine (C5H15N2O3PS) is characterized by an amide group, a sulfone group, a phosphonate group, a carboxylic acid group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.

Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.

The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.

Physical & Chemical Properties

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