2-Methyl-5-(trifluoromethyl)isoindoline CAS 205370-11-2
| CAS No. | 205370-11-2 |
| Molecular Formula | C10H10F3N |
| Molecular Weight | 201.19 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 2-Methyl-5-(trifluoromethyl)isoindoline.
CATO supplies 2-Methyl-5-(trifluoromethyl)isoindoline (CAS 205370-11-2), a certified reference material (molecular formula C10H10F3N, MW 201.19 g/mol) for analytical method development and quality control.
The molecular framework of 2-Methyl-5-(trifluoromethyl)isoindoline (C10H10F3N) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H10F3N |
| Molecular Weight | 201.19 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2015 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Methyl Standards
- 7-Methyl-4-(trifluoromethyl)bicyclo[4.2.0]Octa-1,3,5-trien-7-amine (CAS 1128112-22-0)
- 1-(Trifluoromethyl)-1,2,3,4-tetrahydroisoquinoline (CAS 113721-77-0)
- 5-[(trifluoromethyl)sulfanyl]-1,3,4-thiadiazol-2-amine (CAS 1154962-96-5)
- 2-[2-(Trifluoromethyl)phenyl]cyclopropan-1-amine (CAS 1157693-98-5)
- 3-[3-(Trifluoromethyl)phenyl]azetidine (CAS 1203797-56-1)
- 3-[4-(Trifluoromethyl)phenyl]azetidine (CAS 1203797-84-5)
- (S)-6-(Trifluoromethyl)-2,3-dihydro-1H-inden-1-amine (CAS 1212909-10-8)
- (R)-4-(Trifluoromethyl)-2,3-dihydro-1H-inden-1-amine (CAS 1213068-45-1)
Recommended Standards
- 2-[3-(Trifluoromethyl)phenyl]cyclopropan-1-amine (CAS 2711-57-1)
- 3-((2,3-Difluorophenyl)fluoromethyl)azetidine (CAS 2048224-51-5)
- 2-[(Difluoromethyl)sulfanyl]-1,3-benzoxazole (CAS 943-07-7)
- 3-(Trifluoromethyl)-1,2,3,4-tetrahydroisoquinoline (CAS 223915-99-9)
- n-[(7-ethyl-1h-indol-3-yl)methylidene]hydroxylamine (CAS 790263-81-9)
- 1-(5-Bromopyrimidin-2-yl)propan-2-amine (CAS 1410165-72-8)
- 1,2,3,4,7,8-Hexachlorodibenzo-p-dioxin 13C12 (CAS 109719-80-4)
- 3,6-Diaminopyrazine-2,5-dicarboxamide (CAS 203798-32-7)
- Acridine-2,6-diamine (CAS 3407-94-1)
- 1-(4-Fluorobenzenesulfonyl)-azetidine (CAS 871657-66-8)
- 4-[4-(4-Methylbenzenesulfonyl)piperazin-1-yl]benzonitrile (CAS 478046-94-5)
- Neratinib Impurity 60 (CAS CATO-C4X-113460)
- 2-[1-(trifluoromethyl)cyclopropyl]ethan-1-amine (CAS 1369100-74-2)
- Semaglutide impurity 251 (CAS CATO-C4X-2226251)
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