Oxibendazole (Albendazole EP Impurity I) CAS 20559-55-1
| CAS No. | 20559-55-1 |
| Molecular Formula | C12H15N3O3 |
| Molecular Weight | 249.27 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Oxibendazole (Albendazole EP Impurity I) (C12H15N3O3) is characterized by an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
As a process- or degradation-related impurity, Oxibendazole (Albendazole EP Impurity I) (CAS 20559-55-1, C12H15N3O3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C12H15N3O3 |
| Molecular Weight | 249.27 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1962 |
| Nitrogen Atoms | 3 |
Related Oxibendazole Standards
Recommended Standards
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- Terbutaline impurity 102 (CAS CATO-C4X-1183102)
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- Methyl 3-bromo-5-hydroxy-2-methylbenzoate (CAS 2092700-79-1)
- Tert-butyl (3-azabicyclo[3.2.1]Octan-6-yl)carbamate (CAS 1822851-61-5)
- 4,4,5,5-Tetramethyl-2-[spiro[4.5]dec-7-en-8-yl]-1,3,2-dioxaborolane (CAS 859219-41-3)
- (R)-1-(2,2-Difluorobenzo[d][1,3]dioxol-4-yl)ethan-1-amine hydrochloride (CAS 1257106-39-0)
- D-Ser32-Tirzepatide (CAS CATO-CPTD788692)
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