3-Nitro-5-(trifluoromethyl)benzamide CAS 20566-89-6
| CAS No. | 20566-89-6 |
| Molecular Formula | C8H5F3N2O3 |
| Molecular Weight | 234.13 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
3-Nitro-5-(trifluoromethyl)benzamide (CAS 20566-89-6), molecular formula C8H5F3N2O3 and molecular weight 234.13 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 3-Nitro-5-(trifluoromethyl)benzamide (C8H5F3N2O3) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
As a certified reference material (CRM), 3-Nitro-5-(trifluoromethyl)benzamide meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H5F3N2O3 |
| Molecular Weight | 234.13 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1962 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Nitro Standards
- 5-Nitro-2-(trifluoromethyl)benzamide (CAS 1214323-28-0)
- 1-(6-Nitro-4-(trifluoromethyl)pyridin-2-yl)ethan-1-one (CAS 1393570-80-3)
- 1-(4-Nitro-6-(trifluoromethyl)pyridin-2-yl)ethan-1-one (CAS 1393572-27-4)
- 2-Nitro-5-(trifluoromethyl)benzamide (CAS 16499-68-6)
- 2-Nitro-4-(trifluoromethyl)benzamide (CAS 22227-55-0)
- 4-Nitro-2-(trifluoromethyl)benzamide (CAS 22227-54-9)
- 4-Nitro-2-(4H-1,2,4-triazol-4-yl)benzoic acid (CAS 1017791-31-9)
- 8-Nitro-[1,3]dioxolo[4,5-g]isoquinolin-7(6H)-one (CAS 113982-74-4)
Recommended Standards
- 3-Formyl-5-(trifluoromethoxy)benzoic acid (CAS 2167993-22-6)
- 4-(Trifluoromethyl)phthalic Acid (CAS 835-58-5)
- 3-Bromo-N-cyclohexylpropanamide (CAS 33257-32-8)
- 4,6-dichloro-1,7-naphthyridine-3-carbonitrile (CAS 305371-45-3)
- Tebuconazole Solution, 100 mg/L, 1 ml (CAS 80443-41-0)
- 2-(3-Iodopropyl)-5,5-dimethyl-1,3-dioxane (CAS 331818-83-8)
- Ethyl 2-(5-chlorothiophen-2-yl)ethene-1-sulfonate (CAS 234107-51-8)
- 2-{[(4-nitrophenyl)amino]methylidene}-2,3-dihydro-1H-indene-1,3-dione (CAS 40462-01-9)
- Morpholino(3-(piperidin-4-yl)isoxazol-4-yl)methanone (CAS 1334487-51-2)
- 1-[3-(trifluoromethyl)phenyl]cyclohexane-1-carbonitrile (CAS 944351-63-7)
- (<I>S</I>,<I>R</I>,<I>S</I>)-AHPC hydrochloride (CAS 1448189-80-7)
- Imrecoxib Impurity 80 (CAS CATO-C4X-237980)
- 1-(1,5-Dimethyl-1h-pyrazol-4-yl)thiourea (CAS 1004451-60-8)
- Semaglutide impurity 236 (CAS CATO-C4X-2226236)
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