4-Amino-5-bromo-2-chloropyrimidine CAS 205672-25-9
| CAS No. | 205672-25-9 |
| Molecular Formula | C4H3BrClN3 |
| Molecular Weight | 208.44 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of 4-Amino-5-bromo-2-chloropyrimidine (C4H3BrClN3) is characterized by a nitrile group, chlorine/bromine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
4-Amino-5-bromo-2-chloropyrimidine (CAS 205672-25-9) is a high-purity analytical reference standard with the molecular formula C4H3BrClN3 and a molecular weight of 208.44 g/mol.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C4H3BrClN3 |
| Molecular Weight | 208.44 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 2015 |
| Halogen Content | Cl/Br-containing |
| Nitrogen Atoms | 3 |
Related Amino Standards
- 2-Amino-6-bromo-3-chloropyrazine (CAS 1082843-72-8)
- 2-Amino-3-bromo-5-chloropyrazine (CAS 76537-18-3)
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Recommended Standards
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- 4-Bromo-2-chloropyridine 1-oxide (CAS 883874-88-2)
- 3-Bromo-5-chloropyridin-4(1H)-one (CAS 70149-40-5)
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