4-Cyclopropyl-2-(trifluoromethyl)aniline CAS 2059941-99-8
| CAS No. | 2059941-99-8 |
| Molecular Formula | C10H10F3N |
| Molecular Weight | 201.19 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of 4-Cyclopropyl-2-(trifluoromethyl)aniline (C10H10F3N) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
4-Cyclopropyl-2-(trifluoromethyl)aniline (CAS 2059941-99-8) is a high-purity analytical reference standard with the molecular formula C10H10F3N and a molecular weight of 201.19 g/mol.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H10F3N |
| Molecular Weight | 201.19 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1997 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Cyclopropyl Standards
- 3-Cyclopropyl-5-(trifluoromethyl)aniline (CAS 1057079-57-8)
- (R)-cyclopropyl(2,4,5-trifluorophenyl)methanamine (CAS 1213314-51-2)
- (S)-cyclopropyl(2,4,5-trifluorophenyl)methanamine (CAS 1213404-15-9)
- (S)-cyclopropyl(3,4,5-trifluorophenyl)methanamine (CAS 1213414-26-6)
- (R)-cyclopropyl(3,4,5-trifluorophenyl)methanamine (CAS 1213914-92-1)
- Cyclopropyl(2,4,5-trifluorophenyl)methanamine (CAS 1270376-82-3)
- Cyclopropyl(3,4,5-trifluorophenyl)methanamine (CAS 1270402-45-3)
- 2-Cyclopropyl-5-(trifluoromethyl)aniline (CAS 1700506-02-0)
Recommended Standards
- 3,3-Diethoxy-1,1,1-trifluoropropan-2-amine (CAS 2168838-41-1)
- 5-(Trifluoromethyl)-1,2,3,4-tetrahydroquinoline (CAS 939758-74-4)
- 3-(Trifluoromethyl)-1,2,3,4-tetrahydroisoquinoline (CAS 223915-99-9)
- 5-(Trifluoromethyl)-2,3-dihydro-1H-inden-1-amine (CAS 808756-84-5)
- 1-(Methylcarbamoyl)piperidine-4-carboxylic acid (CAS 1094413-31-6)
- 5-(methoxymethyl)pyridine-3-carboxylic acid hydrochloride (CAS 1955548-79-4)
- 6-Bromo-4-(difluoromethyl)-5-(hydroxymethyl)pyridin-2-ol (CAS 1805240-42-9)
- 3-(2-Chlorophenyl)-5-methyl-N-(4-(6-methylbenzo[d]thiazol-2-yl)phenyl)isoxazole-4-carboxamide (CAS 349613-51-0)
- 1-(3-Phenylpropyl)piperidin-4-amine dihydrochloride (CAS 198896-19-4)
- 3-Bromo-7-fluoro-1H-pyrrolo[3,2-c]pyridine (CAS 1190320-09-2)
- 5-(2-Chloro-5-methylphenyl)pyridine-3-carboxylic acid (CAS 1365272-57-6)
- (2-Methoxy-4,6-dimethylphenyl)methanol (CAS 733768-81-5)
- 2,2,7-Trimethyl-2,3-dihydrobenzofuran-5-carbaldehyde (CAS 363185-40-4)
- Semaglutide impurity 38 (CAS CATO-C4X-222638)
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