(S)-3-amino-6,8-difluoro-2,3-dihydrobenzo[b][1,4]oxazepin-4(5H)-one CAS 2060596-63-4
| CAS No. | 2060596-63-4 |
| Molecular Formula | C9H8F2N2O2 |
| Molecular Weight | 214.17 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including (S)-3-amino-6,8-difluoro-2,3-dihydrobenzo[b][1,4]oxazepin-4(5H)-one.
(S)-3-amino-6,8-difluoro-2,3-dihydrobenzo[b][1,4]oxazepin-4(5H)-one (CAS 2060596-63-4), molecular formula C9H8F2N2O2 and molecular weight 214.17 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of (S)-3-amino-6,8-difluoro-2,3-dihydrobenzo[b][1,4]oxazepin-4(5H)-one (C9H8F2N2O2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), (S)-3-amino-6,8-difluoro-2,3-dihydrobenzo[b][1,4]oxazepin-4(5H)-one meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C9H8F2N2O2 |
| Molecular Weight | 214.17 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1997 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related S Standards
- (R)-3-amino-6,8-difluoro-2,3-dihydrobenzo[b][1,4]oxazepin-4(5H)-one (CAS 2306249-49-8)
- (2-Amino-5-nitrophenyl)dimethylphosphine oxide (CAS 2361936-26-5)
- 2-((5-Amino-1H-1,2,4-triazol-1-yl)methyl)succinic acid (CAS 1144465-02-0)
- (-)-5-Amino-3-(carboxymethyl)-4-oxo-1,4,5,6-tetrahydropyridine-2-carboxylic acid (CAS 78416-84-9)
- 5-Amino-3-(carboxymethyl)-4-oxo-1,4,5,6-tetrahydropyridine-2-carboxylic acid (CAS 84986-74-3)
- Methyl 3-(4-amino-3,5-dioxo-2,3,4,5-tetrahydro-1,2,4-triazin-6-yl)propanoate (CAS 274266-12-5)
- Methyl 2-amino-3-fluoro-5-nitrobenzoate (CAS 1092980-67-0)
- Methyl 2-amino-3-fluoro-6-nitrobenzoate (CAS 1179773-42-2)
Recommended Standards
- 1-(methylsulphonyl)-3-(trifluoromethyl)-1H-pyrazole (CAS 648427-19-4)
- (E)-3-(4,5-difluoro-2-methoxyphenyl)acrylic acid (CAS 886499-69-0)
- 2-(2,3-Dihydrobenzofuran-4-yl)-2,2-difluoroacetic acid (CAS 2870675-19-5)
- (E)-3-(3-(difluoromethoxy)phenyl)acrylic acid (CAS 630424-87-2)
- 2-(3-Chloro-4-fluoro-5-methylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (CAS 1402238-26-9)
- 1-(Pyrimidin-2-yl)piperidine-3-carboxylic acid (CAS 1448854-87-2)
- 2,6-Dimethylnaphthalene-1-carboxylic acid (CAS 33121-71-0)
- 1-Phenyl-5-pyridin-3-yl-1H-pyrazole-3-carboxylic acid (CAS 1052595-22-8)
- Bezafibrate (CAS 41859-67-0)
- 1-(3-Bromophenyl)-1,2-ethanediol (CAS 402937-72-8)
- 3-(3-Aminopyridin-4-yl)benzoic acid (CAS 1822851-49-9)
- 2-[2-(trifluoromethyl)phenoxymethyl]oxirane (CAS 4698-95-7)
- (((2S,3R,4S,5R,6R)-2-(p-Tolylthio)-6-(((trimethylsilyl)oxy)methyl)tetrahydro-2H-pyran-3,4,5-triyl)tris(oxy))tris(trimethylsilane) (CAS 942043-17-6)
- D-Pro36-Tirzepatide (CAS CATO-CPTD788903)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com