6-(Difluoromethyl)nicotinonitrile CAS 206201-65-2
| CAS No. | 206201-65-2 |
| Molecular Formula | C7H4F2N2 |
| Molecular Weight | 154.12 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
6-(Difluoromethyl)nicotinonitrile (CAS 206201-65-2), molecular formula C7H4F2N2 and molecular weight 154.12 g/mol, is a CATO reference standard with documented purity and traceability.
6-(Difluoromethyl)nicotinonitrile (C7H4F2N2) contains a nitrile group, fluorine substitution, an aromatic ring system. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), 6-(Difluoromethyl)nicotinonitrile meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C7H4F2N2 |
| Molecular Weight | 154.12 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2015 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Difluoromethyl Standards
- 6-(Difluoromethyl)picolinonitrile (CAS 1211527-29-5)
- 2-(Difluoromethyl)isonicotinonitrile (CAS 1211528-71-0)
- 4-(Difluoromethyl)nicotinonitrile (CAS 1211579-76-8)
- 3-(Difluoromethyl)pyridine-4-carbonitrile (CAS 1211582-33-0)
- 4-(Difluoromethyl)picolinonitrile (CAS 1211582-77-2)
- 3-(Difluoromethyl)pyridine-2-carbonitrile (CAS 1211583-77-5)
- 5-(Difluoromethyl)nicotinonitrile (CAS 1211585-14-6)
- 2-(Difluoromethyl)nicotinonitrile (CAS 1805192-58-8)
Recommended Standards
- 5-Methyl-6-oxo-1,6-dihydropyridazine-3-carboxylic acid (CAS 87668-16-4)
- 6,7-Dihydro-1H-pyrazolo[5,1-c][1,4]oxazine-2,4-dione (CAS 52867-58-0)
- 5-Methyl-3-oxo-2,3-dihydropyridazine-4-carboxylic acid (CAS 342402-51-1)
- 6-Amino-5-hydroxypicolinic acid (CAS 61548-53-6)
- {8-methyl-5-oxaspiro[3.5]nonan-8-yl}methanamine (CAS 2060005-87-8)
- 3-((1-Benzyl-1H-benzo[d]imidazol-2-yl)thio)propanoic acid (CAS 303132-83-4)
- Ethyl (S)-2-amino-3-(3-chlorophenyl)-2-methylpropanoate (CAS 1241681-61-7)
- 4-Cyano-2-fluoro-N-((3-hydroxy-4-(5-methylbenzo[d]oxazol-2-yl)phenyl)carbamothioyl)benzamide (CAS 593238-87-0)
- 1-(4-Methoxybenzyl)azepan-2-one (CAS 1956354-75-8)
- (S)-2-Amino-N-(((S)-1-benzylpyrrolidin-2-yl)methyl)-N-cyclopropyl-3-methylbutanamide (CAS 1401666-61-2)
- 4-Methyl-2-Hydrazinobenzothiazole (CAS 20174-68-9)
- 2-Bromo-3-methyl-1-(1,2,3,4-tetrahydroisoquinolin-2-yl)butan-1-one (CAS 1017030-81-7)
- 1-(2-Chlorophenyl)-5-ethyl-1H-1,2,3-triazole-4-carboxylic acid (CAS 1017458-30-8)
- Fragment-[9-31]-Semaglutide (CAS CATO-C4X-2226181)
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