3-Chloroisoxazole-5-carboxylic acid CAS 20724-56-5
| CAS No. | 20724-56-5 |
| Molecular Formula | C4H2ClNO3 |
| Molecular Weight | 147.52 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 3-Chloroisoxazole-5-carboxylic acid.
3-Chloroisoxazole-5-carboxylic acid (CAS 20724-56-5) is a high-purity analytical reference standard with the molecular formula C4H2ClNO3 and a molecular weight of 147.52 g/mol.
The molecular framework of 3-Chloroisoxazole-5-carboxylic acid (C4H2ClNO3) is characterized by an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 3-Chloroisoxazole-5-carboxylic acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C4H2ClNO3 |
| Molecular Weight | 147.52 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1962 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Chloroisoxazole Standards
Recommended Standards
- 3-Chloro-4-nitropyrazole (CAS 35852-75-6)
- 5-Chloro-4-nitro-1H-imidazole (CAS 57531-38-1)
- 2-Oxo-2,3-dihydrooxazole-5-carbonyl chloride (CAS 64843-26-1)
- 2-Chlorooxazole-4-carboxylic Acid (CAS 706789-07-3)
- 3-methyloxane-4-sulfonyl chloride (CAS 1420895-90-4)
- 1-Chloro-2-methyldecane (CAS 1491467-17-4)
- 2-Aminoethyl carbamate hydrochloride (CAS 73711-22-5)
- 3-Bromo-1-(2,3-dihydro-1H-inden-5-yl)propan-1-one (CAS 113364-57-1)
- 2-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-4-(4-chlorophenyl)-4-oxobutanoic acid (CAS 1337915-30-6)
- Methyl 5-amino-1H-pyrrolo[3,2-b]pyridine-7-carboxylate (CAS 2231676-76-7)
- Methyl (E)-2-cyano-3-methoxyacrylate (CAS 55883-89-1)
- methyl 4-(2-chlorophenyl)-5-cyano-2-oxo-6-sulfanyl-3,4-dihydro-1H-pyridine-3-carboxylate;4-methylmorpholine (CAS 1078161-58-6)
- 2-(1-(1H-indazol-6-yl)-2,5-dimethyl-1H-pyrrol-3-yl)-2-oxoacetic acid (CAS 866008-98-2)
- D-[γ-Glu](Side Chain)-Semaglutide (CAS CATO-C4X-2226254)
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