(3-Chloro-4-fluorophenyl)(4-fluoro-4-(hydroxymethyl)piperidin-1-yl)methanone CAS 208111-36-8
| CAS No. | 208111-36-8 |
| Molecular Formula | C13H14ClF2NO2 |
| Molecular Weight | 289.71 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including (3-Chloro-4-fluorophenyl)(4-fluoro-4-(hydroxymethyl)piperidin-1-yl)methanone.
(3-Chloro-4-fluorophenyl)(4-fluoro-4-(hydroxymethyl)piperidin-1-yl)methanone (CAS 208111-36-8) is a high-purity analytical reference standard with the molecular formula C13H14ClF2NO2 and a molecular weight of 289.71 g/mol.
Structurally, (3-Chloro-4-fluorophenyl)(4-fluoro-4-(hydroxymethyl)piperidin-1-yl)methanone (C13H14ClF2NO2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 6.0, corresponding to approximately 6 ring(s) or double-bond equivalent(s). With a molecular weight of 289.71 g/mol, it falls into the medium-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), (3-Chloro-4-fluorophenyl)(4-fluoro-4-(hydroxymethyl)piperidin-1-yl)methanone meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C13H14ClF2NO2 |
| Molecular Weight | 289.71 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2016 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related Chloro Standards
- (2-Chloro-5-nitrophenyl)(2,4-dimethylphenyl)methanone (CAS 113456-94-3)
- 2-((3-Chloro-2-methylphenyl)carbamoyl)benzoic acid (CAS 17332-26-2)
- 2-((4-Chloro-2-methylphenyl)carbamoyl)benzoic acid (CAS 19368-31-1)
- 2-((3-Chloro-4-methylphenyl)carbamoyl)benzoic acid (CAS 19368-34-4)
- (2-Chloro-5-nitrophenyl)(3,4-dimethylphenyl)methanone (CAS 70132-77-3)
- (E)-4-chloro-2-(((2,3-dihydrobenzo[b][1,4]dioxin-6-yl)imino)methyl)phenol (CAS 382156-27-6)
- 2-(2-Chloro-4-formylphenoxy)-N-phenylacetamide (CAS 792945-92-7)
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Recommended Standards
- (7-Amino-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)(3-chlorophenyl)methanone (CAS 878969-60-9)
- (7-Amino-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)(4-chlorophenyl)methanone (CAS 696628-26-9)
- [(4Z)-4,5,6,7-Tetrahydro-1-benzofuran-4-ylidene]amino 4-chlorobenzoate (CAS 478047-98-2)
- 3-(Benzo[d][1,3]dioxol-5-yl)-7-chloro-3,4-dihydro-2H-benzo[b][1,4]oxazine (CAS 1713174-08-3)
- (S)-N-(2-Oxotetrahydrofuran-3-yl)pentanamide (CAS 148497-11-4)
- NDI26-2ThBr (CAS 1320282-67-4)
- 5-Chloro-3-cyclopropoxy-N,N-dimethylpicolinamide (CAS 1243375-62-3)
- tert-Butyl 4-(5-(methoxycarbonyl)-6-methylpyridin-2-yl)piperazine-1-carboxylate (CAS 1355174-68-3)
- 3-Cyclopropoxy-4-ethylaniline (CAS 1243375-67-8)
- DL-Ornithine hydrochloride (CAS 1069-31-4)
- Morinidazole Impurity 6 (CAS 1782143-94-5)
- 4-(4-Methoxybenzyl)tetrahydro-2h-pyran-4-carbonitrile (CAS 1393330-62-5)
- 2-Methyl-3-(prop-2-ynoylamino)benzoic acid (CAS 1342365-77-8)
- Tau Peptide (301-315) trifluoroacetate salt (CAS 330456-48-9)
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