(E)-3-(2-Fluoro-phenyl)-acryloyl chloride CAS 208922-47-8

Purity 97%+In StockPharmaceutical Standards
CAS No.208922-47-8
Molecular FormulaC9H6ClFO
Molecular Weight184.59 g/mol
CategoryPharmaceutical Standards / API Standards
AvailabilityIn Stock

Chemical Structure

(E)-3-(2-Fluoro-phenyl)-acryloyl chloride CAS 208922-47-8 chemical structure

Description

Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including (E)-3-(2-Fluoro-phenyl)-acryloyl chloride.

(E)-3-(2-Fluoro-phenyl)-acryloyl chloride (CAS 208922-47-8) is a high-purity analytical reference standard with the molecular formula C9H6ClFO and a molecular weight of 184.59 g/mol.

The molecular framework of (E)-3-(2-Fluoro-phenyl)-acryloyl chloride (C9H6ClFO) is characterized by a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.

This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.

CATO manufactures (E)-3-(2-Fluoro-phenyl)-acryloyl chloride under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.

Physical & Chemical Properties

Molecular FormulaC9H6ClFO
Molecular Weight184.59 g/mol
AppearanceOff-white to pale yellow crystalline powder. (slight halide-like odor, low volatility)
Purity97%+
StorageStore at 2-8°C, protect from light, keep tightly closed to prevent evaporation
Solubility (reference)Soluble in methanol, acetonitrile, DMSO, water (slightly soluble)
StabilityMay oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light
Degree of Unsaturation (DBE)6.0
UV AbsorptionUV-absorbing
Structural FeaturesAromatic ring present
CAS Registry Year (est.)2016
Halogen ContentF/Cl-containing

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