(5-Bromopyrimidin-2-yl)proline CAS 2089658-87-5
| CAS No. | 2089658-87-5 |
| Molecular Formula | C9H10BrN3O2 |
| Molecular Weight | 272.10 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of (5-Bromopyrimidin-2-yl)proline is closely related to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, bromine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
(5-Bromopyrimidin-2-yl)proline (CAS 2089658-87-5), molecular formula C9H10BrN3O2 and molecular weight 272.10 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of (5-Bromopyrimidin-2-yl)proline (C9H10BrN3O2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, bromine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), (5-Bromopyrimidin-2-yl)proline meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C9H10BrN3O2 |
| Molecular Weight | 272.10 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1997 |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 3 |
Related Bromopyrimidin Standards
- (1-(5-Bromopyrimidin-2-yl)piperidin-3-yl)methanol (CAS 1189973-29-2)
- 2-((5-Bromopyrimidin-2-yl)amino)-2-cyclopropylpropan-1-ol (CAS 1394706-57-0)
- 1-(((5-Bromopyrimidin-4-yl)amino)methyl)cyclopentan-1-ol (CAS 1503781-05-2)
- 4-(5-Bromopyrimidin-2-yl)-2,6-dimethylmorpholine (CAS 886366-25-2)
- (5-Bromopyrimidin-2-yl)methyl pivalate (CAS 1400807-81-9)
- 5-(((5-Bromopyrimidin-2-yl)amino)methyl)-2,4-dihydro-3h-1,2,4-triazol-3-one (CAS 1428003-03-5)
- Ethyl 2-(5-bromopyrimidin-2-yl)-2-cyanoacetate (CAS 65364-66-1)
- 1-((5-Bromopyrimidin-2-yl)amino)-3,3-dimethylbutan-2-ol (CAS 1355927-56-8)
Recommended Standards
- rac-(2R,3R)-2-(5-bromopyridin-3-yl)oxolane-3-carboxylic acid (CAS 1969288-45-6)
- 1-(2,2-Difluoropropyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole (CAS 2648779-27-3)
- Methyl 3-(5-bromo-2-methoxypyridin-3-yl)acrylate (CAS 1956426-85-9)
- 1-(4-Bromo-2-nitrophenyl)-2-(propan-2-ylidene)hydrazine (CAS 914636-18-3)
- 4-(2-Ethylfuran-3-yl)benzene-1,2-diamine (CAS 471239-83-5)
- 2-Methoxyethyl 4-(2,5-dimethoxyphenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate (CAS 300690-04-4)
- 3'-propenyl-4'-hydroxyacetophenone (CAS 1132-05-4)
- n2-(Cyclopropylmethyl)-1-(furan-2-yl)-n1,n1-dimethylethane-1,2-diamine (CAS 1156283-59-8)
- 4,6-Dichloro-2-cyclopropylpyrimidine (CAS 7043-09-6)
- (2Z)-1,7,7-trimethyl-n-(prop-2-yn-1-yloxy)bicyclo[2.2.1]heptan-2-imine (CAS 314238-36-3)
- tricyclo[5.2.1.0^{2,6}]decane-2-carboxylic acid (CAS 148810-36-0)
- 4-(3-(4-Chlorophenyl)-1H-1,2,4-triazol-5-yl)-2-methoxyphenol (CAS 1416347-55-1)
- 2-Methyl-1-[(4-nitrophenyl)methyl]piperazine (CAS 1240572-91-1)
- Insulin Glulisine (CAS 207748-29-6)
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