4-(Difluoromethyl)-5-fluoro-2-nitrophenol CAS 2092102-06-0
| CAS No. | 2092102-06-0 |
| Molecular Formula | C7H4F3NO3 |
| Molecular Weight | 207.11 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
4-(Difluoromethyl)-5-fluoro-2-nitrophenol (CAS 2092102-06-0) is a high-purity analytical reference standard with the molecular formula C7H4F3NO3 and a molecular weight of 207.11 g/mol.
4-(Difluoromethyl)-5-fluoro-2-nitrophenol (C7H4F3NO3) contains an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 4-(Difluoromethyl)-5-fluoro-2-nitrophenol meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C7H4F3NO3 |
| Molecular Weight | 207.11 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1997 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Difluoromethyl Standards
- 2-(Difluoromethyl)-5-fluoro-3-hydroxypyridine-6-carboxylic acid (CAS 1804703-04-5)
- 3-(Difluoromethyl)-4-fluoro-5-nitropyridin-2-amine (CAS 1804730-76-4)
- 6-(Difluoromethyl)-5-fluoro-3-nitropyridin-2-amine (CAS 1804730-81-1)
- 4-(Difluoromethyl)-2-fluoro-6-hydroxynicotinic acid (CAS 1805036-88-7)
- 5-(Difluoromethyl)-2-fluoro-3-nitropyridin-4-amine (CAS 1805062-32-1)
- 5-(Difluoromethyl)-3-fluoro-4-nitropyridin-2-amine (CAS 1805115-98-3)
- 2-(Difluoromethyl)-4-fluoro-6-hydroxypyridine-3-carboxylic acid (CAS 1805190-04-8)
- 4-(Difluoromethyl)-5-fluoro-3-nitropyridin-2-amine (CAS 1805342-47-5)
Recommended Standards
- 4-(Difluoromethoxy)-1-fluoro-2-nitrobenzene (CAS 57213-30-6)
- 4-Amino-2-trifluoromethyl-pyrimidine-5-carboxylic acid (CAS 777-43-5)
- 4-(Bromomethyl)-3,3-dimethyltetrahydro-2H-pyran (CAS 2091216-50-9)
- 4-Hydroxy-2-(trifluoromethyl)nicotinic acid (CAS 956576-89-9)
- 1,2,4-Thiadiazol-5-amine (CAS 7552-07-0)
- 3-(4-Ethylphenyl)-N-(4h-1,2,4-triazol-3-yl)propanamide (CAS 1050837-23-4)
- Dropropizine N-Oxide (CAS 152323-00-7)
- N-Hydroxy MDA hydrochloride (CAS 74341-83-6)
- 1-(3-Ethylureido)-1-oxopropan-2-yl 2-(methylthio)nicotinate (CAS 747410-12-4)
- 1-(Tert-Butyl)-5-Chloro-1H-Pyrazole-4-Carboxylic Acid (CAS 950858-13-6)
- Methyl 5-bromo-2-methyl-1H-pyrrolo[2,3-b]pyridine-3-carboxylate (CAS 1228551-75-4)
- 3-Amino-N-(4-chlorophenyl)propanamide hydrochloride (CAS 1245568-68-6)
- 3-[(4-Pyridinylmethyl)amino]-1-propanol hydrochloride (CAS 1216431-19-4)
- Semaglutide Impurity 8 (CAS CATO-C4X-22268)
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