Diazepam EP Impurity E CAS 20927-53-1
| CAS No. | 20927-53-1 |
| Molecular Formula | C15H11ClN2O |
| Molecular Weight | 270.71 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Structurally, Diazepam EP Impurity E (C15H11ClN2O) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 11.0, corresponding to approximately 11 ring(s) or double-bond equivalent(s). With a molecular weight of 270.71 g/mol, it falls into the medium-molecular-weight range. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
CATO supplies Diazepam EP Impurity E (CAS 20927-53-1), a pharmacopoeial impurity reference standard (molecular formula C15H11ClN2O, MW 270.71 g/mol) used for the identification and quantification of trace impurities in APIs.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Diazepam EP Impurity E meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C15H11ClN2O |
| Molecular Weight | 270.71 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1962 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Diazepam Standards
- 【禁售不询】Diazepam EP impurity A (CAS 1088-11-5)
- Diazepam Impurity 12 (CAS CATO-C4X-146512)
- Diazepam Impurity 10 (CAS CATO-C4X-146510)
- Diazepam (CAS 439-14-5)
- Diazepam EP Impurity C (CAS 5220-02-0)
- Diazepam EP Impurity F (CAS 31269-33-7)
- Diazepam Impurity 11 (CAS CATO-C4X-146511)
- Diazepam Impurity 12 (CAS 36271-03-1)
Recommended Standards
- Indometacin Impurity 16 (CAS CATO-C4X-147016)
- Alprazolam Impurity 5 (CAS 5220-83-7)
- Paliperidone Impurity 158 (CAS CATO-C4X-1724158)
- Azelastine EP Impurity D (CAS 53242-88-9)
- Atogepant Impurity 68 (CAS CATO-C4X-328568)
- Sorafenib Impurity 61 (CAS CATO-C4X-112461)
- Gentamicin Impurity 24 (CAS CATO-C4X-148024)
- 2-Chloro-3-nitrobenzenesulfonyl chloride (CAS 15945-25-2)
- 4-Aminobutanamide hydrochloride (CAS 13031-62-4)
- 5-Amino-3-((4-chlorophenoxy)methyl)-1-methyl-1H-pyrazole-4-carbonitrile (CAS 1260740-11-1)
- Methyl 6-bromo-1-methylindoline-4-carboxylate (CAS 1629879-87-3)
- 2-Amino-2-mercaptopropanoic acid (CAS 72087-33-3)
- 1-Cyclopropyl-2,2,2-trifluoroethyl methanesulfonate (CAS 2126163-06-0)
- Peptide 439 (CAS CATO-CPTD788439)
Why CATO?
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