(E)-3-(5-Chloropyridin-2-yl)acrylaldehyde CAS 2098967-54-3
| CAS No. | 2098967-54-3 |
| Molecular Formula | C8H6ClNO |
| Molecular Weight | 167.59 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
(E)-3-(5-Chloropyridin-2-yl)acrylaldehyde (CAS 2098967-54-3) is a high-purity analytical reference standard with the molecular formula C8H6ClNO and a molecular weight of 167.59 g/mol.
The molecular framework of (E)-3-(5-Chloropyridin-2-yl)acrylaldehyde (C8H6ClNO) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), (E)-3-(5-Chloropyridin-2-yl)acrylaldehyde meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H6ClNO |
| Molecular Weight | 167.59 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1997 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related E Standards
- N-((6-chloropyridin-3-yl)methyl)cyanamide (CAS 491593-46-5)
- 2-(2-Chloropyridin-3-yl)propanenitrile (CAS 1225479-05-9)
- 3-(3-Chloropyridin-4-yl)propanenitrile (CAS 1483129-41-4)
- 2-(6-Chloropyridin-3-yl)propanenitrile (CAS 866629-20-1)
- 2-[(6-chloropyridin-3-yl)oxy]acetonitrile (CAS 1517936-85-4)
- 2-((5-Chloropyridin-2-yl)oxy)acetonitrile (CAS 643014-41-9)
- 1-(4-Chloropyridin-2-yl)cyclopropan-1-amine (CAS 1060808-97-0)
- 1-(4-Chloropyridin-3-yl)cyclopropan-1-amine (CAS 1060808-98-1)
Recommended Standards
- 3-Chloro-5-methylbenzo[d]isoxazole (CAS 196708-35-7)
- (R)-2-(4-Chlorophenyl)-2-hydroxyacetonitrile (CAS 97070-79-6)
- 4-(Chloromethyl)benzo[d]oxazole (CAS 1935479-66-5)
- (R)-2-chloro-N-(2,3-dihydroxypropyl)acetamide (CAS 919286-64-9)
- n-(1-Methoxybutan-2-yl)-3,3-dimethylcyclohexan-1-amine (CAS 1343061-32-4)
- 2-(Propylamino)pyridine-3-sulfonamide (CAS 1247456-99-0)
- N-Cyclopropyl-N-(piperidin-3-ylmethyl)acetamide (CAS 1353977-58-8)
- 4-(((5-Bromothiophen-2-yl)methylene)amino)-3-(3-ethoxyphenyl)-1H-1,2,4-triazole-5(4H)-thione (CAS 613249-88-0)
- (1-Cyclopropylethyl)hydrazine dihydrochloride (CAS 1181458-56-9)
- (R)-3-(Fluoromethyl)-1-((S)-1-(trityloxy)-propan-2-yl)pyrrolidine (CAS 1443983-95-6)
- N-(tert-Butoxycarbonyl)glycine Ethyl Ester (CAS 14719-37-0)
- 15-Mercaptopentadecanoic acid (CAS 184639-70-1)
- 1-(5-Bromo-1h-indol-2-yl)ethan-1-amine (CAS 1270476-46-4)
- Biotinyl-Neuropeptide W-23 (human) (CAS 1815618-09-7)
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