1-(2,4-Bis-difluoromethoxy-phenyl)-ethanone CAS 210816-49-2
| CAS No. | 210816-49-2 |
| Molecular Formula | C10H8F4O3 |
| Molecular Weight | 252.16 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of 1-(2,4-Bis-difluoromethoxy-phenyl)-ethanone (C10H8F4O3) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
CATO supplies 1-(2,4-Bis-difluoromethoxy-phenyl)-ethanone (CAS 210816-49-2), a certified reference material (molecular formula C10H8F4O3, MW 252.16 g/mol) for analytical method development and quality control.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H8F4O3 |
| Molecular Weight | 252.16 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2017 |
| Halogen Content | F-containing |
Related Bis Standards
- 3-Difluoromethoxy-6-(trifluoromethyl)pyridine-2-acetonitrile (CAS 1227583-25-6)
- Methyl 4-(difluoromethoxy)-1-naphthoate (CAS 1261559-96-9)
- 4-(4-(Difluoromethoxy)phenyl)-2-hydrazinylpyrimidine (CAS 932240-78-3)
- 2-Difluoromethoxy-3-(trifluoromethoxy)benzonitrile (CAS 1803734-58-8)
- 5-Difluoromethoxy-2-(trifluoromethoxy)benzonitrile (CAS 1803734-74-8)
- 2-Difluoromethoxy-5-(trifluoromethoxy)benzonitrile (CAS 1803792-09-7)
- 4-Difluoromethoxy-2-(trifluoromethoxy)benzonitrile (CAS 1803832-70-3)
- 2-Difluoromethoxy-4-(trifluoromethoxy)benzonitrile (CAS 1804416-39-4)
Recommended Standards
- (2,3-Dihydrospiro[indene-1,2'-[1,3]dithiolan]-5-yl)boronic acid (CAS 915402-16-3)
- 1-cyclobutyl-5-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole (CAS 2227297-73-4)
- 6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazolo[1,5-a]pyridine (CAS 1873385-99-9)
- 2-(benzofuran-3-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (CAS 796851-30-4)
- 1-[4-(Chloromethyl)phenyl]-1H-pyrazole (CAS 143426-52-2)
- 2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-5,5-dimethylhexanoic acid (CAS 1379863-59-8)
- 4-Allyl-1-benzylpiperidin-4-ol (CAS 883291-28-9)
- 5-Boc-amino-benzoimidazole (CAS 885270-97-3)
- N-(2-furylmethyl)acetamide (CAS 5663-62-7)
- 3-Amino-N-(4-methoxyphenyl)benzamide (CAS 115175-19-4)
- 2-(2-Morpholinophenoxy)acetic acid (CAS 1523566-52-0)
- 2-Iodo-5-(trifluoromethyl)-[1,2,4]triazolo[1,5-a]pyridine (CAS 2060593-54-4)
- 2-(2-Fluoroethyl)-1H-benzo[d]imidazole (CAS 1379342-09-2)
- Semaglutide impurity 38 (CAS CATO-C4X-222638)
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