3-Acetyl-5-amino-1,3,4-thiadiazol-2(3H)-one CAS 211388-16-8
| CAS No. | 211388-16-8 |
| Molecular Formula | C4H5N3O2S |
| Molecular Weight | 159.17 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
3-Acetyl-5-amino-1,3,4-thiadiazol-2(3H)-one (CAS 211388-16-8) is a high-purity analytical reference standard with the molecular formula C4H5N3O2S and a molecular weight of 159.17 g/mol.
The molecular framework of 3-Acetyl-5-amino-1,3,4-thiadiazol-2(3H)-one (C4H5N3O2S) is characterized by an amide group, a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C4H5N3O2S |
| Molecular Weight | 159.17 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 2017 |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 1 |
Related Acetyl Standards
- (5-Amino-[1,3,4]thiadiazol-2-yl)-acetic acid (CAS 118863-94-8)
- 2-Acetyl-5-amino-1,2,4-thiadiazol-3(2H)-one (CAS 220966-98-3)
- 2-Amino-4-methyl-5-nitrothiazole (CAS 56682-07-6)
- 4-Amino-1,2,5-thiadiazole-3-carbohydrazide (CAS 6972-14-1)
- 5-Amino-1,3,4-thiadiazole-2-carbohydrazide (CAS 98022-46-9)
- 5-Amino-2-thioxodihydropyrimidine-4,6(1H,5H)-dione (CAS 98019-74-0)
- 5-Amino-6-thioxo-dihydro-pyrimidine-2,4-dione (CAS 34771-17-0)
- Methyl 4-amino-1,2,5-thiadiazole-3-carboxylate (CAS 63875-18-3)
Recommended Standards
- 2-Hydrazinylthiazole-4-carboxylic acid (CAS 67618-36-4)
- 3-Methyl-4-nitroisothiazol-5-amine (CAS 40184-32-5)
- 3-Methyl-6-thioxo-1,3,5-triazinane-2,4-dione (CAS 59045-41-9)
- 4-(Methylamino)-1,2,5-thiadiazole-3-carboxylic acid (CAS 89033-42-1)
- 2,7-Dimethylisoquinolin-1(2H)-one (CAS 118160-07-9)
- Bis(2-((S)-4-isopropyl-4,5-dihydrooxazol-2-yl)phenyl)amine (CAS 485394-20-5)
- 6-(2-methylpropoxy)pyridin-3-ol (CAS 1256786-97-6)
- 4-(Trifluoromethyl)cyclohex-1-enylboronic acid (CAS 865869-30-3)
- Methyl 6-(butylamino)-5-nitronicotinate (CAS 1820735-46-3)
- (2S,3R,4S,5R)-2-Acetoxy-5-((benzoyloxy)methyl)tetrahydrofuran-3,4-diyl dibenzoate (CAS 16162-35-9)
- 2-(5-Bromo-3-chloro-2-fluorophenyl)-1,3-dioxolane (CAS 2504204-09-3)
- 4IL61GN3YI 7758-95-4 Lead chloride Lead chloride (PbCl2) Lead dichloride CCRIS 7565 EINECS 231-845-5 HSDB 6309 Lead(2+) chloride Lead (II) chloride Lead(II) chloride Plumbous chloride UNII-4IL61GN3YI EC 231-845-5 (CAS 7758-95-4)
- 2H-Phenanthro[9,10-d][1,2,3]triazole (CAS 236-03-3)
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