2-(5-Ethoxy-2-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane CAS 2121512-83-0
| CAS No. | 2121512-83-0 |
| Molecular Formula | C14H20BFO3 |
| Molecular Weight | 266.12 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 2-(5-Ethoxy-2-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane.
2-(5-Ethoxy-2-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (CAS 2121512-83-0), molecular formula C14H20BFO3 and molecular weight 266.12 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 2-(5-Ethoxy-2-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (C14H20BFO3) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C14H20BFO3 |
| Molecular Weight | 266.12 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1997 |
| Halogen Content | F-containing |
Related Ethoxy Standards
- 2-(4-Ethoxy-3-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (CAS 1147106-23-7)
- 2-(3-Ethoxy-5-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (CAS 1416367-03-7)
- 2-(3-Ethoxy-2-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (CAS 1509931-76-3)
- 2-(3-Ethoxy-4-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (CAS 1688673-02-0)
- 2-(2-Ethoxy-4-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (CAS 1688702-57-9)
- 2-(2-Ethoxy-6-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (CAS 1689470-54-9)
- 2-(2-Ethoxy-3-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (CAS 2246767-21-3)
- 1-Ethoxy-2-fluoro-4-iodobenzene (CAS 1208075-88-0)
Recommended Standards
- 2-(4-Fluoro-3-methoxy-5-methylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (CAS 2121514-30-3)
- 2-(6-Fluoro-2-methoxy-3-methylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (CAS 2121513-01-5)
- 2-(4-Fluoro-2-methoxy-5-methylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (CAS 2096334-36-8)
- 2-Bromo-5-methyl-4,5-dihydro-7H-pyrazolo[5,1-d][1,2,5]thiadiazine 6,6-dioxide (CAS 2246370-77-2)
- 5-(Furan-3-yl)-2-methylaniline (CAS 1190222-20-8)
- Wz4141 (CAS 1222776-76-2)
- 2-[(4S)-4,5-Dihydro-4-phenyl-2-oxazolyl]-5-methylphenol (CAS 2837261-91-1)
- 3-Piperidin-3-ylmethyl-isoquinoline dihydrochloride (CAS 1187928-56-8)
- Bis-propargyl-PEG7 (CAS 1351373-46-0)
- 2-((4-Chlorophenyl)thio)-5-nitropyridine (CAS 25935-61-9)
- 2,9-Di(anthracen-9-yl)-1,10-phenanthroline (CAS 204195-52-8)
- 2-(2-Cyclohexylethyl)-3-ethylpyrrolidine (CAS 525537-46-6)
- 1-Methyl-4-nitro-1H-pyrazol-3-ol (CAS 1458593-78-6)
- Liraglutide Impurity 22 (CAS 536721-25-2)
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