2-(4-Chloro-5-cyano-pyrrolo[2,3-d]pyrimidin-7-yl)acetic acid CAS 2122273-77-0

Purity 97%+In StockPharmaceutical Standards
CAS No.2122273-77-0
Molecular FormulaC9H5ClN4O2
Molecular Weight236.61 g/mol
CategoryPharmaceutical Standards / API Standards
AvailabilityIn Stock

Chemical Structure

2-(4-Chloro-5-cyano-pyrrolo[2,3-d]pyrimidin-7-yl)acetic acid CAS 2122273-77-0 chemical structure

Description

This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.

2-(4-Chloro-5-cyano-pyrrolo[2,3-d]pyrimidin-7-yl)acetic acid (CAS 2122273-77-0) is a high-purity analytical reference standard with the molecular formula C9H5ClN4O2 and a molecular weight of 236.61 g/mol.

The molecular framework of 2-(4-Chloro-5-cyano-pyrrolo[2,3-d]pyrimidin-7-yl)acetic acid (C9H5ClN4O2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.

As a certified reference material (CRM), 2-(4-Chloro-5-cyano-pyrrolo[2,3-d]pyrimidin-7-yl)acetic acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.

Physical & Chemical Properties

Molecular FormulaC9H5ClN4O2
Molecular Weight236.61 g/mol
AppearancePale yellow to yellow crystalline powder. (slight halide-like odor, faint amine-like odor)
Purity97%+
StorageStore at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation
Solubility (reference)Soluble in DMSO, DMF, methanol
StabilityMay oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions
Degree of Unsaturation (DBE)9.0
UV AbsorptionUV-absorbing
Structural FeaturesAromatic ring present
CAS Registry Year (est.)1997
Halogen ContentCl-containing
Nitrogen Atoms4

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