4,4,5,5-Tetramethyl-2-(4-(2-(trifluoromethyl)oxetan-2-yl)phenyl)-1,3,2-dioxaborolane CAS 2133473-11-5
| CAS No. | 2133473-11-5 |
| Molecular Formula | C16H20BF3O3 |
| Molecular Weight | 328.13 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies 4,4,5,5-Tetramethyl-2-(4-(2-(trifluoromethyl)oxetan-2-yl)phenyl)-1,3,2-dioxaborolane (CAS 2133473-11-5), a certified reference material (molecular formula C16H20BF3O3, MW 328.13 g/mol) for analytical method development and quality control.
The molecular framework of 4,4,5,5-Tetramethyl-2-(4-(2-(trifluoromethyl)oxetan-2-yl)phenyl)-1,3,2-dioxaborolane (C16H20BF3O3) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 4,4,5,5-Tetramethyl-2-(4-(2-(trifluoromethyl)oxetan-2-yl)phenyl)-1,3,2-dioxaborolane meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C16H20BF3O3 |
| Molecular Weight | 328.13 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1997 |
| Halogen Content | F-containing |
Related Tetramethyl Standards
- 4,4,5,5-Tetramethyl-2-(5-(trifluoromethyl)benzo[b]thiophen-2-yl)-1,3,2-dioxaborolane (CAS 1184850-41-6)
- 4,4,5,5-Tetramethyl-2-(7-(trifluoromethyl)benzo[b]thiophen-2-yl)-1,3,2-dioxaborolane (CAS 1310384-44-1)
- 3-[4-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyrazol-1-ylmethyl]-benzoic acid (CAS 1450642-63-3)
- 6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)spiro[indoline-3,4'-piperidin]-2-one (CAS 1384162-44-0)
- 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)cyclohex-3-en-1-yl benzoate (CAS 2121513-44-6)
- 4,4,5,5-Tetramethyl-2-(pyren-2-yl)-1,3,2-dioxaborolane (CAS 853377-11-4)
- 4,4,5,5-tetramethyl-2-(pyren-4-yl)-1,3,2-dioxaborolane (CAS 888950-09-2)
- 4,4,5,5-Tetramethyl-2-pyren-1-yl-1,3,2-dioxaborolane (CAS 349666-24-6)
Recommended Standards
- 6-(4-Iodophenyl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole (CAS 1071415-66-1)
- 5-(1-Bromoethyl)-2-(dimethoxymethyl)-3-(trifluoromethyl)pyridine (CAS 2853570-64-4)
- methyl 4-fluoro-3-iodo-1H-indazole-6-carboxylate (CAS 885521-35-7)
- Ethyl 3-(4-bromo-2-fluorophenyl)-5-methylisoxazole-4-carboxylate (CAS 334971-45-8)
- Potassium Propyl 4-Hydroxybenzoate Solution, 100pm (CAS 84930-16-5)
- 2-(Trifluoromethoxy)aniline (CAS 1535-75-7)
- 2-Chloro-5-(trifluoromethoxy)benzaldehyde (CAS 468075-02-7)
- N-([1,1'-Biphenyl]-2-yl)-4-methyl-3-(piperidin-1-ylsulfonyl)benzamide (CAS 750625-29-7)
- tert-Butyl 4-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)piperidine-1-carboxylate (CAS 1177559-55-5)
- Amoxicillin Impurity 109 (CAS CATO-C4X-1148109)
- 4-(4-(Tert-butyl)benzoyl)-N-((tetrahydrofuran-2-yl)methyl)-1H-pyrrole-2-carboxamide (CAS 478078-29-4)
- 5-methyl-1,7-dihydropyrrolo[2,3-d]pyrimidine-2,4-dione (CAS 67856-03-5)
- 2-(Hydroxymethyl)-2-(methoxymethyl)quinuclidin-3-one (CAS 5291-32-7)
- Semaglutide impurity 199 (CAS CATO-C4X-2226199)
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