2-(2,6-Difluorophenyl)pyrrolidine hydrochloride CAS 2135331-85-8
| CAS No. | 2135331-85-8 |
| Molecular Formula | C10H11F2N |
| Molecular Weight | N/A |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 2-(2,6-Difluorophenyl)pyrrolidine hydrochloride.
2-(2,6-Difluorophenyl)pyrrolidine hydrochloride (CAS 2135331-85-8) is a high-purity analytical reference standard with the molecular formula C10H11F2NHCl and a molecular weight of 219.66 g/mol.
2-(2,6-Difluorophenyl)pyrrolidine hydrochloride (C10H11F2NHCl) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/chlorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H11F2N HCl |
| Molecular Weight | 219.66 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1997 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related Difluorophenyl Standards
- 1-(1-(2,6-Difluorophenyl)-5-methyl-1H-1,2,4-triazol-3-yl)ethanone (CAS 1000572-09-7)
- (2,4-Difluorophenyl)methanesulfonamide (CAS 1001026-56-7)
- Methyl 2-(2,3-difluorophenyl)-2-hydroxyacetate (CAS 1001159-03-0)
- 2-(2,4-Difluorophenyl)cyclopropan-1-amine (CAS 1001318-18-8)
- (4R)-4-(2,4-difluorophenyl)pyrrolidine-3-carbonitrile (CAS 1002728-74-6)
- N-(2,5-Difluorophenyl)-3-methylbenzamide (CAS 1002813-62-8)
- 4-(3,5-Difluorophenyl)piperidinehydrochloride (CAS 1004618-89-6)
- 4-(2,3-difluorophenyl)piperidine hydrochloride (CAS 1004618-90-9)
Recommended Standards
- 6-Bromoimidazo[1,2-a]pyrimidin-2-amine (CAS 1103861-39-7)
- Terbuthylazine D5 (ethyl D5) (CAS 222986-60-9)
- Tert-butyl (4-formylbicyclo[2.1.1]Hexan-1-yl)carbamate (CAS 2387597-71-7)
- Bis(2-acetylmercaptoethyl) sulfone (CAS 17096-46-7)
- 4-(5-Fluoro-1H-benzo[d]imidazol-2-yl)phenol (CAS 156144-39-7)
- N1,N1-dimethylbicyclo[1.1.1]Pentane-1,3-diamine hydrochloride (CAS 2231674-46-5)
- N-Methyl-2-oxo-1,2-dihydropyridine-3-sulfonamide (CAS 1710661-73-6)
- (3R,4S)-4-Methoxytetrahydrofuran-3-amine (CAS 1909294-55-8)
- 6-(4-Oxothiazolidin-2-yl)hexanoic acid (CAS 539-35-5)
- Semaglutide impurity 271 (CAS CATO-C4X-2226271)
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