1-Bromo-2-(phenylethynyl)benzene CAS 21375-88-2
| CAS No. | 21375-88-2 |
| Molecular Formula | C14H9Br |
| Molecular Weight | 257.13 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
1-Bromo-2-(phenylethynyl)benzene (CAS 21375-88-2), molecular formula C14H9Br and molecular weight 257.13 g/mol, is a CATO reference standard with documented purity and traceability.
Owing to bromine substitution, a polycyclic aromatic system, 1-Bromo-2-(phenylethynyl)benzene is typically pale yellow to yellow low-melting solid. Its solid-state physicochemical attributes — including a molecular weight of 257.13 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C14H9Br |
| Molecular Weight | 257.13 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1963 |
| Halogen Content | Br-containing |
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Recommended Standards
- 12-bromo-7-methyl-4-oxa-7,11-diazatricyclo[7.3.0.0²,⁶]dodeca-1(12),9-diene (CAS 2104549-86-0)
- 1-Bromoanthracene (CAS 7397-92-4)
- 1-(6-Bromopyridin-2-yl)piperidin-3-ol (CAS 959239-10-2)
- 1-Bromophenanthrene (CAS 51958-51-1)
- (R)-1-(4-Morpholinophenyl)ethan-1-ol (CAS 1225049-48-8)
- 1-propyl-1H-pyrrole-2-carbaldehyde (CAS 89686-22-6)
- 2-(ethylsulfanyl)-6-fluoroaniline (CAS 1182828-59-6)
- (E)-4-[5-[2-[4-(2-Chlorophenyl)-5-[5-(methylsulfonyl)-2-pyridyl]-4H-1,2,4-triazol-3-yl]vinyl]-1,3,4-oxadiazol-2-yl]benzonitrile (CAS 1380672-07-0)
- Fosravuconazole (CAS 351227-64-0)
- 4-(Difluoromethyl)-6-iodo-3-nitropyridin-2-ol (CAS 1805208-11-0)
- Napipitant Impurity 5 (CAS CATO-C4X-34855)
- (3S)-1-(trideuteriomethyl)pyrrolidin-3-amine (CAS 2694068-60-3)
- 1'-(Tert-butoxycarbonyl)spiro[chromane-2,4'-piperidine]-4-carboxylic acid (CAS 1009375-04-5)
- Semaglutide impurity 67 (CAS CATO-C4X-222667)
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