Metoclopramide Impurity 96 CAS 21386-96-9
| CAS No. | 21386-96-9 |
| Molecular Formula | C9H8ClNO4 |
| Molecular Weight | 229.62 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Metoclopramide Impurity 96 (CAS 21386-96-9, C9H8ClNO4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Metoclopramide Impurity 96 (C9H8ClNO4) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C9H8ClNO4 |
| Molecular Weight | 229.62 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1963 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Metoclopramide Standards
- Metoclopramide Impurity 32 (CAS 476614-80-9)
- Metoclopramide Impurity 67 (CAS CATO-C4X-141567)
- Metoclopramide Impurity 26 (CAS CATO-C4X-141526)
- Metoclopramide EP Impurity D (CAS 4093-29-2)
- Metoclopramide impurity 81 (CAS CATO-C4X-141581)
- Metoclopramide Impurity 19 (CAS 1279870-17-5)
- Metoclopramide Impurity 89 (CAS CATO-C4X-141589)
- Metoclopramide Impurity 119 (CAS CATO-C4X-1415119)
Recommended Standards
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- 2-Methyl-3-(methylsulfanyl)aniline (CAS 60710-81-8)
- 61704-30-1 6-(4-Chlorophenyl)pyridine-2-carbaldehyde DTXSID90494575 (CAS 61704-30-1)
- Palmitoyl Tripeptide-1 HCl (CAS 2757690-14-3)
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