Metaraminol Impurity 8 CAS 21480-44-4
| CAS No. | 21480-44-4 |
| Molecular Formula | C9H13NO2 |
| Molecular Weight | 167.21 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Metaraminol Impurity 8 is closely related to an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
CATO supplies Metaraminol Impurity 8 (CAS 21480-44-4), a pharmacopoeial impurity reference standard (molecular formula C9H13NO2, MW 167.21 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Metaraminol Impurity 8 (C9H13NO2) is characterized by an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C9H13NO2 |
| Molecular Weight | 167.21 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (faint amine-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1963 |
| Nitrogen Atoms | 1 |
Related Metaraminol Standards
- Metaraminol Impurity 27 (CAS 21480-43-3)
- Metaraminol Impurity 30 (CAS 54-49-9)
- Metaraminol Impurity 41 (CAS 61-59-6)
- Metaraminol Impurity 56 (CAS CATO-C4X-225256)
- Metaraminol Impurity 52 (CAS CATO-C4X-225252)
- Metaraminol Impurity 27 (CAS 78523-29-2)
- Metaraminol Impurity 10 (CAS 639070-81-8)
- Metaraminol Impurity 18 (CAS CATO-C4X-225218)
Recommended Standards
- Niraparib Impurity 36 (CAS 1140736-91-9)
- Drotaverine Impurity 14 (CAS 5763-61-1)
- Deferiprone Impurity 9 (CAS CATO-C4X-30489)
- L-Phenylephrine (CAS 59-42-7)
- Zolpidem Tartrate EP Impurity C (CAS 4619-20-9)
- Crisaborole Impurity 39 (CAS 2227126-13-6)
- Rabeprazole EP Impurity I (CAS 924663-37-6)
- (2R,3R,4S,5S)-2-(6-Amino-9H-purin-9-yl)-5-(((3-(methylamino)propyl)thio)methyl)tetrahydrofuran-3,4-diol (CAS 59452-68-5)
- 8-bromo-2-methylimidazo[1,2-a]pyridine (CAS 1194374-75-8)
- 9-Chloro-2-phenyl-[1,2,4]triazolo[1,5-c]quinazolin-5(6H)-one (CAS 104614-95-1)
- Imidazo[1,2-a]pyridin-2-amine hydrochloride (CAS 1993100-43-8)
- 4-Cyclopentylaniline (CAS 20029-53-2)
- 2-Chloro-N-(3-chlorophenyl)-2-phenylacetamide (CAS 50916-14-8)
- Semaglutide impurity 200 (CAS CATO-C4X-2226200)
Why CATO?
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