3-(Difluoromethyl)-2-(2,3,4-trimethoxyphenyl)-1H-indole CAS 2149597-56-6
| CAS No. | 2149597-56-6 |
| Molecular Formula | C18H17F2NO3 |
| Molecular Weight | 333.33 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 3-(Difluoromethyl)-2-(2,3,4-trimethoxyphenyl)-1H-indole.
3-(Difluoromethyl)-2-(2,3,4-trimethoxyphenyl)-1H-indole (CAS 2149597-56-6), molecular formula C18H17F2NO3 and molecular weight 333.33 g/mol, is a CATO reference standard with documented purity and traceability.
Structurally, 3-(Difluoromethyl)-2-(2,3,4-trimethoxyphenyl)-1H-indole (C18H17F2NO3) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 10.0, corresponding to approximately 10 ring(s) or double-bond equivalent(s). With a molecular weight of 333.33 g/mol, it falls into the moderately-high-molecular-weight range. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures 3-(Difluoromethyl)-2-(2,3,4-trimethoxyphenyl)-1H-indole under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C18H17F2NO3 |
| Molecular Weight | 333.33 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1997 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Difluoromethyl Standards
- 2-[4-(difluoromethyl)-3-methyl-6-oxo-1-phenyl-1h,6h,7h-pyrazolo[3,4-b]pyridin-7-yl]acetic acid (CAS 1018052-39-5)
- 2-(Difluoromethyl)-3-hydroxy-4-iodopyridine-5-carbonyl chloride (CAS 1805258-17-6)
- 2-(Difluoromethyl)-3-hydroxy-4-iodopyridine-6-carbonyl chloride (CAS 1805479-68-8)
- 2-(Difluoromethyl)-6-hydroxy-5-iodopyridine-3-carbonyl chloride (CAS 1805479-75-7)
- 2-(Difluoromethyl)-5-hydroxy-3-iodopyridine-4-carbonyl chloride (CAS 1805542-69-1)
- 2-(Difluoromethyl)-3-hydroxy-6-iodopyridine-5-carbonyl chloride (CAS 1805606-95-4)
- 2-(Difluoromethyl)-4-hydroxy-6-iodopyridine-3-carbonyl chloride (CAS 1805995-29-2)
- 2-(Difluoromethyl)-5-hydroxy-6-iodopyridine-3-carbonyl chloride (CAS 1805995-38-3)
Recommended Standards
- 3-(2,4-Difluorophenyl)-1-[4-(morpholin-4-yl)phenyl]urea (CAS 866156-01-6)
- 3-Phenyl-5-(phenylsulfanyl)-6-(trifluoromethyl)-1,2,4-triazine (CAS 478048-14-5)
- 2-(tert-Butylsulfonyl)-2-{2-[4-(trifluoromethyl)phenyl]hydrazono}acetonitrile (CAS 338976-14-0)
- 4-(3-(Benzyloxy)-4-(difluoromethoxy)phenyl)pyrrolidin-2-one (CAS 885056-45-1)
- N-((5-cyanofuran-2-yl)methyl)-N,N-diethylethanaminium bromide (CAS 1044731-69-2)
- 1-(Benzo[d]thiazol-2-yl)-3-(4-chlorophenyl)-1H-pyrazol-5-ol (CAS 378203-46-4)
- 9-Methyl-5-tosyl-5,6-dihydroindeno[2,1-b]indole (CAS 185376-48-1)
- 4-(Benzyloxy)-7-azaindole (CAS 1260761-21-4)
- 1-(1,4-Diazepan-1-yl)ethanone dihydrochloride (CAS 1389313-58-9)
- N-(5-Bromo-3-methyl-2-pyridinyl)-N-propylamine (CAS 1219982-70-3)
- 2-(Pyridin-3-ylcarbamoyl)benzoic acid (CAS 38370-61-5)
- 2-(Methylthio)quinoline-6-thiol (CAS 54002-19-6)
- Ethyl 6-(2-(3,4-diethoxyphenyl)thiazol-4-yl)picolinate (CAS 145739-58-8)
- Peptide Impurity 04 (CAS 2913424-91-4)
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