2-Bromo-1-(2,4-difluoro-3-(trifluoromethoxy)phenyl)ethan-1-one CAS 2149602-08-2
| CAS No. | 2149602-08-2 |
| Molecular Formula | C9H4BrF5O2 |
| Molecular Weight | 319.02 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
2-Bromo-1-(2,4-difluoro-3-(trifluoromethoxy)phenyl)ethan-1-one (CAS 2149602-08-2), molecular formula C9H4BrF5O2 and molecular weight 319.02 g/mol, is a CATO reference standard with documented purity and traceability.
2-Bromo-1-(2,4-difluoro-3-(trifluoromethoxy)phenyl)ethan-1-one (C9H4BrF5O2) contains a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/bromine substitution, an aromatic ring system. Halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C9H4BrF5O2 |
| Molecular Weight | 319.02 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1997 |
| Halogen Content | F/Br-containing |
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Recommended Standards
- 4,5-Dibromo-2-phenylthiazole (CAS 105361-77-1)
- Pyrrole-2,5-bis(boronic acid pinacol ester), 97% (CAS 476004-84-9)
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- (E)-1-(2-Bromovinyl)-3,5-bis(trifluoromethyl)benzene (CAS 1260684-00-1)
- (S)-1-tert-Butyl 2-methyl 5-oxopiperidine-1,2-dicarboxylate (CAS 915976-31-7)
- 1-(2-Amino-4-(trifluoromethyl)phenyl)-2,2,2-trifluoroethan-1-one (CAS 1448858-61-4)
- N-(3-Sulfamoylphenyl)guanidine (CAS 4431-64-5)
- 8-Isocyanoquinoline (CAS 3101-17-5)
- 2-(((4-Acetylphenyl)amino)methyl)-5-nitroisoindoline-1,3-dione (CAS 301207-13-6)
- Sodium 5-((4-chloro-6-((3-sulfonatophenyl)amino)-1,3,5-triazin-2-yl)amino)-4-hydroxy-3-((4-((2-sulfonatoethyl)sulfonyl)phenyl)diazenyl)naphthalene-2,7-disulfonate (CAS 145017-98-7)
- 5-Phenyl-5-(pyridin-4-yl)imidazolidine-2,4-dione (CAS 54743-30-5)
- Peficitinib Impurity 14 (CAS 944123-02-8)
- (4,4-Difluorocyclohex-1-en-1-yl)boronic acid (CAS 1401165-15-8)
- Semaglutide impurity 237 (CAS CATO-C4X-2226237)
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