1,3-Dimethyl-6-((2,2,2-trifluoroethyl)amino)pyrimidine-2,4(1H,3H)-dione CAS 21544-65-0
| CAS No. | 21544-65-0 |
| Molecular Formula | C8H12F3N3O2 |
| Molecular Weight | 239.19 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
1,3-Dimethyl-6-((2,2,2-trifluoroethyl)amino)pyrimidine-2,4(1H,3H)-dione (CAS 21544-65-0) is a high-purity analytical reference standard with the molecular formula C8H12F3N3O2 and a molecular weight of 239.19 g/mol.
The molecular framework of 1,3-Dimethyl-6-((2,2,2-trifluoroethyl)amino)pyrimidine-2,4(1H,3H)-dione (C8H12F3N3O2) is characterized by an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H12F3N3O2 |
| Molecular Weight | 239.19 g/mol |
| Appearance | White to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1963 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
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Recommended Standards
- 1,1,1-trifluoro-4-(1H-indol-3-yl)but-3-en-2-one (CAS 401607-52-1)
- 1-[3-nitro-5-(trifluoromethyl)phenyl]ethanone (CAS 39174-87-3)
- 1,1,1-Trifluoro-3-(quinolin-2-yl)propan-2-one (CAS 398-50-5)
- 2-(1-(2,2,2-Trifluoroacetyl)piperidin-4-yl)acetic acid (CAS 933477-85-1)
- 6-Methoxy-4,4-dimethyl-3,4-dihydronaphthalen-1(2H)-one (CAS 23203-51-2)
- (2R)-1-(dimethylamino)propan-2-ol (CAS 53636-15-0)
- 2-Nitro-3-trifluoromethoxy-phenylamine (CAS 1261445-43-5)
- 4-Chloro-2-methyl-3-(propan-2-yl)quinoline (CAS 357951-57-6)
- (5-Chloro-6-(thiophen-3-yl)pyridin-3-yl)boronic acid (CAS 2225179-00-8)
- 3,4-Difluoro-2,6-diiodophenol (CAS 1228093-47-7)
- Entacapone Impurity 24 (CAS 4097-63-6)
- Heptanoyl Chloride (CAS 2528-61-2)
- 2-(3-Hydroxyphenyl)ethanol (CAS 13398-94-2)
- Neuropeptide K, porcine (CAS 106441-70-7)
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