1-Ethynyl-2,3,4,5-tetrafluorobenzene CAS 21622-12-8
| CAS No. | 21622-12-8 |
| Molecular Formula | C8H2F4 |
| Molecular Weight | 174.10 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), 1-Ethynyl-2,3,4,5-tetrafluorobenzene meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
1-Ethynyl-2,3,4,5-tetrafluorobenzene (CAS 21622-12-8), molecular formula C8H2F4 and molecular weight 174.10 g/mol, is a CATO reference standard with documented purity and traceability.
1-Ethynyl-2,3,4,5-tetrafluorobenzene (C8H2F4) contains fluorine substitution, an aromatic ring system. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C8H2F4 |
| Molecular Weight | 174.10 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1963 |
| Halogen Content | F-containing |
Related Ethynyl Standards
- 3-Ethynyl-1,2,4,5-tetrafluorobenzene (CAS 69442-35-9)
- 3-Ethynyl-1-(2,2,2-trifluoroethyl)-1h-pyrazole (CAS 1354704-44-1)
- 4-Ethynyl-1-methyl-3-(trifluoromethyl)pyrazole (CAS 1498364-87-6)
- 5-Ethynyl-1-methyl-3-trifluoromethyl-1h-pyrazole (CAS 1855889-41-6)
- 7-Ethynyl-1H-pyrido[2,3-b][1,4]oxazin-2(3H)-one (CAS 1824105-71-6)
- 7-Ethynyl-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one (CAS 1824123-04-7)
- Methyl 4-ethynyl-3-methylbenzoate (CAS 123279-38-9)
- Methyl 3-ethynyl-4-methylbenzoate (CAS 1255099-13-8)
Recommended Standards
- 4,6-Difluorosalicylic acid (CAS 189283-54-3)
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- 2,3-Difluoro-6-nitroaniline (CAS 211693-73-1)
- 1-(1-(3-Chlorophenyl)ethyl)piperidin-3-amine hydrochloride (CAS 1203266-43-6)
- 4-((8-Ethylquinolin-4-yl)oxy)aniline (CAS 1315346-75-8)
- 2-(2-Ethylcyclohexyl)acetic acid (CAS 1341884-10-3)
- 4-[(3-methyl-1,2,4-oxadiazol-5-yl)methyl]aniline hydrochloride (CAS 1461709-33-0)
- (2E)-2-[(1E)-(Methoxyimino)methyl]-3-(4-methoxyphenyl)prop-2-enenitrile (CAS 337919-88-7)
- Promethazine Maleate - API Standards (CAS 27059-74-1)
- Di-tert-butyl (5-fluoro-2-nitrophenyl)iminodicarbonate (CAS 1352302-86-3)
- 1-Chloro-4-((chlorodifluoromethyl)sulfonyl)benzene (CAS 403496-62-8)
- 3-(3-Bromophenyl)-2,3-dimethylpropiophenone (CAS 898760-18-4)
- Semaglutide impurity 23 (CAS CATO-C4X-222623)
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