Flutamide impurity 8 CAS 216665-22-4
| CAS No. | 216665-22-4 |
| Molecular Formula | C11H10BrF3N2O4 |
| Molecular Weight | 371.11 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Flutamide impurity 8 is closely related to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/bromine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Flutamide impurity 8 (CAS 216665-22-4) is a certified pharmaceutical impurity reference standard with the molecular formula C11H10BrF3N2O4 and a molecular weight of 371.11 g/mol.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/bromine substitution, Flutamide impurity 8 is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 371.11 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Flutamide impurity 8 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C11H10BrF3N2O4 |
| Molecular Weight | 371.11 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2018 |
| Halogen Content | F/Br-containing |
| Nitrogen Atoms | 2 |
Related Flutamide Standards
Recommended Standards
- (R)-3-Bromo-2-hydroxy-2-methyl-N-(4-nitro-3-(trifluoromethyl)phenyl)propanamide (CAS 206193-18-2)
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- (1S,2S,3R,4S)-Diethyl 4-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)cyclohexane-1,2-dicarboxylate (CAS 860642-65-5)
- 6-Bromo-3-(trifluoromethyl)quinoxalin-2(1H)-one (CAS 2589532-88-5)
- 3-(Isopentyloxy)-4-methoxybenzaldehyde (CAS 722504-38-3)
- 4-(Difluoromethyl)-1-(2-methylpropyl)-1h-pyrazole-3-carboxylic acid (CAS 1423029-57-5)
- Ethyl (E)-3,4-dimethylpent-2-enoate (CAS 21016-44-4)
- 2-(4-((4-Chlorobenzyl)oxy)phenyl)-5-(dimethylamino)oxazole-4-carbonitrile (CAS 844461-41-2)
- Semaglutide impurity 60 (CAS CATO-C4X-222660)
Why CATO?
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