1-Acetyl-4-fluoropiperidine-4-carboxylic acid CAS 2167348-18-5
| CAS No. | 2167348-18-5 |
| Molecular Formula | C8H12FNO3 |
| Molecular Weight | 189.18 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 1-Acetyl-4-fluoropiperidine-4-carboxylic acid is closely related to an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
CATO supplies 1-Acetyl-4-fluoropiperidine-4-carboxylic acid (CAS 2167348-18-5), a certified reference material (molecular formula C8H12FNO3, MW 189.18 g/mol) for analytical method development and quality control.
1-Acetyl-4-fluoropiperidine-4-carboxylic acid (C8H12FNO3) contains an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 1-Acetyl-4-fluoropiperidine-4-carboxylic acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H12FNO3 |
| Molecular Weight | 189.18 g/mol |
| Appearance | White to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1998 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Acetyl Standards
- 4-Benzyl-4-fluoropiperidine (CAS 191327-89-6)
- 1-Benzyl-4-fluoropiperidine (CAS 764664-42-8)
- 4-Fluoropiperidine-1-sulfonyl chloride (CAS 1224929-82-1)
- 3-Fluoropiperidine-1-sulfonyl chloride (CAS 1845693-87-9)
- Ethyl 3-fluoropiperidine-3-carboxylate (CAS 1111640-63-1)
- ethyl 4-fluoropiperidine-4-carboxylate (CAS 845958-77-2)
- methyl 5-fluoropiperidine-3-carboxylate (CAS 1241725-62-1)
- Methyl 3-fluoropiperidine-4-carboxylate (CAS 1303972-83-9)
Recommended Standards
- 1-[2-(Trifluoromethyl)phenyl]ethylamine Hydrochloride (CAS 39959-68-7)
- 2-(5-((1H-1,2,4-triazol-1-yl)methyl)-1H-1,2,4-triazol-3-yl)acetonitrile (CAS 477852-49-6)
- 1,1,1-Trifluoro-3-phenylpropan-2-amine (CAS 404-20-6)
- 2,2,2-Trifluoro-1-(m-tolyl)ethanamine (CAS 886368-58-7)
- (R)-2-Ethynyl-2-methylcyclohexanone (CAS 2749965-88-4)
- (S)-1-(pyridin-3-yl)propan-2-ol (CAS 1432620-26-2)
- 4-Methoxy-5-methylthieno[2,3-d]pyrimidine-6-carboxylic acid (CAS 101668-00-2)
- CAS 285138-85-4 (CAS 285138-85-4)
- Ethyl-alpha-13C-benzene (CAS 287399-32-0)
- 2-(Furan-2-yl)-5-{[(3-methylphenyl)methyl]sulfanyl}-1,3,4-oxadiazole (CAS 477856-54-5)
- 5-(3-Cyanophenyl)furan-2-carboxylic acid (CAS 253679-32-2)
- 4-(4-Chlorobenzoyl)piperidine Hydrochloride (CAS 55695-51-7)
- (R)-2-(2,4,6-Trimethylbenzyl)piperazine (CAS 1240582-37-9)
- Semaglutide impurity 26 (CAS CATO-C4X-222626)
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