Tert-butyl (7,7-difluoro-2-azaspiro[3.4]Octan-6-yl)carbamate CAS 2168292-89-3
| CAS No. | 2168292-89-3 |
| Molecular Formula | C12H20F2N2O2 |
| Molecular Weight | 262.30 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies Tert-butyl (7,7-difluoro-2-azaspiro[3.4]Octan-6-yl)carbamate (CAS 2168292-89-3), a certified reference material (molecular formula C12H20F2N2O2, MW 262.30 g/mol) for analytical method development and quality control.
The molecular framework of Tert-butyl (7,7-difluoro-2-azaspiro[3.4]Octan-6-yl)carbamate (C12H20F2N2O2) is characterized by an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), Tert-butyl (7,7-difluoro-2-azaspiro[3.4]Octan-6-yl)carbamate meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C12H20F2N2O2 |
| Molecular Weight | 262.30 g/mol |
| Appearance | White to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1998 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Recommended Standards
- Tert-butyl (3S,6S)-6-(aminomethyl)-1,1-difluoro-5-azaspiro[2.4]Heptane-5-carboxylate (CAS 2306255-51-4)
- Tert-butyl (R)-5-amino-7,7-difluoro-2-azaspiro[3.4]Octane-2-carboxylate (CAS 2306250-07-5)
- Tert-butyl (3R,6S)-6-(aminomethyl)-1,1-difluoro-5-azaspiro[2.4]Heptane-5-carboxylate (CAS 2306248-39-3)
- Tert-butyl (S)-5-amino-7,7-difluoro-2-azaspiro[3.4]Octane-2-carboxylate (CAS 2306248-16-6)
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