Tert-butyl 2-(aminomethyl)-3,3-difluoroazetidine-1-carboxylate CAS 2169154-56-5
| CAS No. | 2169154-56-5 |
| Molecular Formula | C9H16F2N2O2 |
| Molecular Weight | 222.23 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Tert-butyl 2-(aminomethyl)-3,3-difluoroazetidine-1-carboxylate (CAS 2169154-56-5), molecular formula C9H16F2N2O2 and molecular weight 222.23 g/mol, is a CATO reference standard with documented purity and traceability.
Owing to an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, Tert-butyl 2-(aminomethyl)-3,3-difluoroazetidine-1-carboxylate is typically white to off-white crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 222.23 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C9H16F2N2O2 |
| Molecular Weight | 222.23 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 2.0 |
| CAS Registry Year (est.) | 1998 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Recommended Standards
- tert-Butyl (S)-(4,4-difluoropyrrolidin-3-yl)carbamate (CAS 2166050-86-6)
- Tert-butyl 3,3-difluoropiperazine-1-carboxylate (CAS 2387594-86-5)
- tert-Butyl (R)-4-amino-3,3-difluoropyrrolidine-1-carboxylate (CAS 2199214-47-4)
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- [(6-Chloro-3,4-dimethyl-2-oxo-2H-chromen-7-yl)oxy]acetic acid (CAS 884497-67-0)
- 2-Butyl-1H-imidazole-4,5-dicarbonitrile (CAS 114772-25-7)
- 2-Mercapto-5-((4-methoxyphenyl)sulfonyl)pyrimidin-4-ol (CAS 931965-85-4)
- FMRF-Like Peptide from snail Helix aspersa (CAS 98495-35-3)
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