4-Bromo-2-methylbenzoyl chloride CAS 21900-45-8
| CAS No. | 21900-45-8 |
| Molecular Formula | C8H6BrClO |
| Molecular Weight | 233.49 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), 4-Bromo-2-methylbenzoyl chloride meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
4-Bromo-2-methylbenzoyl chloride (CAS 21900-45-8), molecular formula C8H6BrClO and molecular weight 233.49 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 4-Bromo-2-methylbenzoyl chloride (C8H6BrClO) is characterized by a hydroxyl group, an ether linkage, chlorine/bromine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C8H6BrClO |
| Molecular Weight | 233.49 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1963 |
| Halogen Content | Cl/Br-containing |
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Recommended Standards
- 4-Bromo-2-chloro-3-methylbenzaldehyde (CAS 2010198-18-0)
- 4-Bromo-3-methylbenzoyl chloride (CAS 21900-25-4)
- 4-Bromo-2-chloro-1-(vinyloxy)benzene (CAS 869569-67-5)
- 4-Bromo-6-chloro-1,3-dihydroisobenzofuran (CAS 2828462-22-0)
- 1,2-dimethyl (1R,2R)-4-oxocyclohexane-1,2-dicarboxylate (CAS 159910-01-7)
- 7-Methoxy-3,4-dihydroquinazolin-4-one (CAS 16064-24-7)
- 2-azido-1,4-dichlorobenzene (CAS 75458-15-0)
- Lumateperone Impurity 24 (CAS CATO-C4X-220124)
- 4-Methyl-N-[(5-methylthiophen-2-yl)methyl]aniline (CAS 51306-05-9)
- 7-methoxy-[1,2,4]triazolo[4,3-a]pyridine-3-carboxylic acid (CAS 1159831-01-2)
- 2-(3,5-Difluoro-4-(isopentyloxy)phenyl)ethanol (CAS 1443355-11-0)
- 4-Bromo-2-isopropyl-5-methoxypyridazin-3(2H)-one (CAS 186792-16-5)
- Ethyl 3-bromo-4,5-difluorobenzoate (CAS 1805523-26-5)
- Semaglutide impurity 85 (CAS CATO-C4X-222685)
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