3-(Trifluoromethoxy)benzenesulfonyl chloride CAS 220227-84-9
| CAS No. | 220227-84-9 |
| Molecular Formula | C7H4ClF3O3S |
| Molecular Weight | 260.62 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
3-(Trifluoromethoxy)benzenesulfonyl chloride (CAS 220227-84-9), molecular formula C7H4ClF3O3S and molecular weight 260.62 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 3-(Trifluoromethoxy)benzenesulfonyl chloride (C7H4ClF3O3S) is characterized by a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
CATO manufactures 3-(Trifluoromethoxy)benzenesulfonyl chloride under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C7H4ClF3O3S |
| Molecular Weight | 260.62 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2019 |
| Halogen Content | F/Cl-containing |
| Sulfur Atoms | 1 |
Related Trifluoromethoxy Standards
- 2-(Trifluoromethoxy)benzenesulfonyl Chloride (CAS 103008-51-1)
- {1-[4-(trifluoromethoxy)phenyl]pyrrolidin-3-yl}methanamine (CAS 1016813-33-4)
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- (S)-2-(2-(Trifluoromethoxy)benzyl)piperazine (CAS 1240589-70-1)
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Recommended Standards
- 2-Chlorophenyl trifluoromethanesulfonate (CAS 66107-36-6)
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- 4-Chlorophenyltriflate (CAS 29540-84-9)
- (4-((3-(Dimethylamino)propyl)amino)phenyl)boronic acid (CAS 1268398-37-3)
- 3-(5-Methylthiophen-3-yl)benzoic acid (CAS 1486290-82-7)
- 3-Acetyl-N-benzyloxycarbonyl-4-O-benzyl-L-tyrosine Methyl Ester (CAS 105205-69-4)
- 3-Chloro-5-fluoro-2-iodobenzophenone (CAS 951890-42-9)
- 2-Methoxy-4-(trifluoromethyl)benzoyl chloride (CAS 886500-49-8)
- Methyl 4-bromo-3-carbamoylbenzoate (CAS 2140305-53-7)
- 1-((1R,5S)-6,6-Dimethylbicyclo[3.1.1]hept-2-en-2-yl)-N-((2'-iodo-[1,1'-biphenyl]-4-yl)methyl)-N,N-dimethylmethanaminium iodide (CAS 1414376-85-4)
- (R)-2-Amino-2-(4-aminophenyl)acetic acid (CAS 35619-39-7)
- N-[3-Methyl-1-(5-methyl-1H-1,3-benzodiazol-2-yl)butyl]benzamide (CAS 338410-57-4)
- Peptide YY (3-36) (human) (CAS 123583-37-9)
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