5-(4-(Trifluoromethyl)phenyl)oxazole-4-carboxylic acid CAS 220652-95-9
| CAS No. | 220652-95-9 |
| Molecular Formula | C11H6F3NO3 |
| Molecular Weight | 257.17 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of 5-(4-(Trifluoromethyl)phenyl)oxazole-4-carboxylic acid (C11H6F3NO3) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
5-(4-(Trifluoromethyl)phenyl)oxazole-4-carboxylic acid (CAS 220652-95-9), molecular formula C11H6F3NO3 and molecular weight 257.17 g/mol, is a CATO reference standard with documented purity and traceability.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), 5-(4-(Trifluoromethyl)phenyl)oxazole-4-carboxylic acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C11H6F3NO3 |
| Molecular Weight | 257.17 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2020 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Trifluoromethyl Standards
- 5-[2-(trifluoromethyl)phenyl]-1,2-oxazole-4-carboxylic acid (CAS 1003561-80-5)
- 1-[5-(trifluoromethyl)pyridin-2-yl]-1h-pyrazole-3-carboxylic acid (CAS 1006962-72-6)
- 1-[2-(trifluoromethyl)phenyl]-1h-1,2,3-triazole-4-carboxylic acid (CAS 1049872-71-0)
- 4-(5-(Trifluoromethyl)isoxazol-3-yl)benzoic acid (CAS 1124198-95-3)
- 1-[3-(trifluoromethyl)phenyl]-1h-1,2,3-triazole-4-carboxylic acid (CAS 113934-33-1)
- 5-[3-(Trifluoromethyl)phenyl]isoxazole-3-carboxylic Acid (CAS 1188086-34-1)
- 4-Oxo-5-(trifluoromethyl)-1,4-dihydroquinoline-3-carboxylic acid (CAS 1221573-16-5)
- 1-Phenyl-5-(trifluoromethyl)-1h-1,2,3-triazole-4-carboxylic acid (CAS 1221724-12-4)
Recommended Standards
- 5-(3-Bromophenyl)-2-methylpentan-2-ol (CAS 87077-89-2)
- 5-(Trifluoromethyl)-3-phenylisoxazole-4-carboxylic Acid (CAS 478081-67-3)
- 4-Oxo-8-(trifluoromethyl)-1,4-dihydroquinoline-3-carboxylic acid (CAS 31601-88-4)
- 5-[2-(Trifluoromethyl)phenyl]isoxazole-3-carboxylic Acid (CAS 668971-05-9)
- 95314-60-6 Benzenepropanoic acid, ?-acetyl-4-bromo-, ethyl ester (CAS 95314-60-6)
- 1-(4-Ethoxyphenyl)-5-ethyl-1H-1,2,3-triazole-4-carboxylic acid (CAS 1017416-73-7)
- Ethyl 2-(3-bromoquinolin-6-yl)acetate (CAS 1393353-34-8)
- N-(tert-butoxycarbonyl)-S-(4-methylbenzyl)-D-homocysteine (CAS 214630-13-4)
- 1-(5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)furan-3-yl)ethan-1-one (CAS 1111096-31-1)
- Methyl 2'-fluoro-[1,1'-biphenyl]-3-carboxylate (CAS 80254-83-7)
- 2-(4-Fluoro-3-methyl-2-(trifluoromethyl)phenyl)acetonitrile (CAS 1706446-60-7)
- N-ethyl-N-[(tridecafluorohexyl)sulphonyl]glycine (CAS 68957-32-4)
- Fmoc-(2S,3S)-2-amino-3-phenylbutanoic acid (CAS 247175-69-5)
- Peptide Impurity 28 (CAS 1350456-64-2)
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