3-(2-Fluoroethoxy)isoxazole-5-carbaldehyde CAS 220780-49-4
| CAS No. | 220780-49-4 |
| Molecular Formula | C6H6FNO3 |
| Molecular Weight | 159.12 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO supplies 3-(2-Fluoroethoxy)isoxazole-5-carbaldehyde (CAS 220780-49-4), a certified reference material (molecular formula C6H6FNO3, MW 159.12 g/mol) for analytical method development and quality control.
The molecular framework of 3-(2-Fluoroethoxy)isoxazole-5-carbaldehyde (C6H6FNO3) is characterized by an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
As a certified reference material (CRM), 3-(2-Fluoroethoxy)isoxazole-5-carbaldehyde meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C6H6FNO3 |
| Molecular Weight | 159.12 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2020 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Fluoroethoxy Standards
- 5-(2-Fluoroethoxy)pyridazin-3(2H)-one (CAS 1346697-95-7)
- 3-(2-fluoroethoxy)cyclobutane-1-carboxylic acid (CAS 1708160-35-3)
- 2-(2-Fluoroethoxy)aniline (CAS 1547-11-1)
- 4-(2-Fluoroethoxy)aniline (CAS 1547-12-2)
- 3-(2-Fluoroethoxy)aniline (CAS 1764-82-5)
- 1-(2-Fluoroethoxy)-2-methylbenzene (CAS 123644-37-1)
- 1,2-Bis(2-Fluoroethoxy)Ethane (CAS 63938-33-0)
- 3-(2-Fluoroethoxy)benzonitrile (CAS 132838-24-5)
Recommended Standards
- (S)-4-(Fluoromethylene)-5-oxopyrrolidine-2-carboxylic acid (CAS 728034-35-3)
- 3-(2-Fluoroethyl)isoxazole-4-carboxylic acid (CAS 2452464-97-8)
- 2-amino-2-(4-fluorofuran-3-yl)acetic acid (CAS 1822544-84-2)
- 3-(Ethoxycarbonyl)oxirane-2-carboxylic acid (CAS 68521-71-1)
- 7,7-Difluoro-3-azaspiro[5.5]Undecane (CAS 2168042-94-0)
- 2-Cyano-3-(2,5-dichlorophenyl)propionic Acid (CAS 2044707-21-1)
- (1Z)-N-Hydroxy-4-pyrrolidin-1-ylbutanimidamide (CAS 885952-00-1)
- N-(4-(3-Bromophenyl)thiazol-2-yl)-3-methylbut-2-enamide (CAS 773861-05-5)
- (2R,4R)-Pentane-2,4-diylbis(bis(3,5-dimethylphenyl)phosphine) (CAS 217648-63-0)
- Palonosetron Impurity 21 2HCl (CAS 2216746-63-1（free base）)
- 3-{5-methyl-3H-imidazo[4,5-b]pyridin-2-yl}aniline (CAS 1533523-21-5)
- 2-Cyclooctenol (CAS 3212-75-7)
- (S)-DIPPA hydrochloride (CAS 155512-52-0)
- Semaglutide impurity 331 (CAS CATO-C4X-2226231)
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