Ethyl 8-bromoquinoline-4-carboxylate CAS 220844-75-7
| CAS No. | 220844-75-7 |
| Molecular Formula | C12H10BrNO2 |
| Molecular Weight | 280.12 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
Ethyl 8-bromoquinoline-4-carboxylate (CAS 220844-75-7), molecular formula C12H10BrNO2 and molecular weight 280.12 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of Ethyl 8-bromoquinoline-4-carboxylate (C12H10BrNO2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, bromine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C12H10BrNO2 |
| Molecular Weight | 280.12 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2020 |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 1 |
Related Ethyl Standards
- Ethyl 6-bromoquinoline-2-carboxylate (CAS 1020572-61-5)
- Ethyl 2-bromoquinoline-4-carboxylate (CAS 104997-49-1)
- ethyl 7-bromoquinoline-2-carboxylate (CAS 1196153-95-3)
- Ethyl 7-Bromoquinoline-3-carboxylate (CAS 1226762-74-8)
- Ethyl 4-bromoquinoline-3-carboxylate (CAS 1242260-12-3)
- Ethyl 5-Bromoquinoline-3-carboxylate (CAS 1383551-36-7)
- Ethyl 6-bromoquinoline-8-carboxylate (CAS 1823235-14-8)
- Ethyl 5-bromoquinoline-8-carboxylate (CAS 1823300-65-7)
Recommended Standards
- Ethyl 8-bromoquinoline-3-carboxylate (CAS 347146-14-9)
- Methyl 1-(4-bromophenyl)-1H-pyrrole-2-carboxylate (CAS 439094-83-4)
- Ethyl 7-Bromoisoquinoline-3-carboxylate (CAS 660830-62-6)
- Methyl 6-bromo-2-methylquinoline-4-carboxylate (CAS 786659-09-4)
- 6-(Azepan-1-yl)-4-methylnicotinonitrile (CAS 1355195-62-8)
- Ethyl 2-(2-amino-4-methyl-1,3-thiazol-5-yl)acetate (CAS 78468-68-5)
- 2-Chloro-5-fluoro-4-thiocyanatopyrimidine (CAS 112889-53-9)
- Tridecyl methacrylate(mixtureofbranchedchainisomers)(stabilizedwithMEHQ) (CAS 2495-25-2)
- 2-{4-[(dimethylamino)methyl]piperidin-1-yl}aniline (CAS 1274732-71-6)
- (3-Formyl-2-methylphenyl)boronic acid (CAS 631909-10-9)
- 7,8-Dimethyl-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (CAS 111185-91-2)
- Ethyl 1-(2-hydroxyethyl)-2-methyl-1H-benzo[d]imidazole-5-carboxylate (CAS 299927-12-1)
- 1-(aminomethyl)-4,4-difluorocyclohexan-1-ol hydrochloride (CAS 1227808-08-3)
- Galanin Message Associated Peptide (1-41) amide trifluoroacetate salt (CAS 132699-74-2)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com