4-Hydroxy-2-methoxybenzyl chloride CAS 221068-32-2
| CAS No. | 221068-32-2 |
| Molecular Formula | C8H9ClO2 |
| Molecular Weight | 172.61 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Owing to a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system, 4-Hydroxy-2-methoxybenzyl chloride is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 172.61 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
4-Hydroxy-2-methoxybenzyl chloride (CAS 221068-32-2) is a high-purity analytical reference standard with the molecular formula C8H9ClO2 and a molecular weight of 172.61 g/mol.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H9ClO2 |
| Molecular Weight | 172.61 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2020 |
| Halogen Content | Cl-containing |
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Recommended Standards
- 4-Chloro-α-methoxybenzenemethanol (CAS 55685-75-1)
- 5-(Chloromethyl)-2-methoxyphenol (CAS 529502-39-4)
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- 5-Chloro-1-ethyl-3-methyl-1H-pyrazole-4-carbaldehyde (CAS 412327-38-9)
- N-Hexyl-N'-phenylurea (CAS 1142-07-0)
- 4-Amino-2-(hydroxymethyl)phenol (CAS 104333-09-7)
- 3,5,6,7-Tetramethoxy-2-(4-methoxyphenyl)-4H-chromen-4-one (CAS 4472-73-5)
- 2-((2,5-Dioxo-1-phenylpyrrolidin-3-yl)thio)benzoic acid (CAS 301229-04-9)
- 2-Chloro-2-phenylethanol (CAS 1004-99-5)
- Cefazedone lactone (CAS 70150-41-3)
- Methyl 2-(methylthio)pyrimidine-5-carboxylate (CAS 38275-41-1)
- tert-Butyl ((2-acetyl-6-cyanopyridin-4-yl)methyl)carbamate (CAS 1393544-37-0)
- tert-Butyl ((2-ethoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-yl)methyl)carbamate (CAS 478375-33-6)
- [a-Glu](Side chain transposition)- Semaglutide (CAS CATO-C4X-2226111)
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