Ethyl 8-methoxychromane-3-carboxylate CAS 221185-47-3
| CAS No. | 221185-47-3 |
| Molecular Formula | C13H16O4 |
| Molecular Weight | 236.26 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Ethyl 8-methoxychromane-3-carboxylate (CAS 221185-47-3), molecular formula C13H16O4 and molecular weight 236.26 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of Ethyl 8-methoxychromane-3-carboxylate (C13H16O4) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), Ethyl 8-methoxychromane-3-carboxylate meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C13H16O4 |
| Molecular Weight | 236.26 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2020 |
Related Ethyl Standards
- Ethyl 6-methoxychromane-3-carboxylate (CAS 885271-71-6)
- Ethyl 7-methoxychromane-3-carboxylate (CAS 885271-77-2)
- Methyl 7-methoxychromane-3-carboxylate (CAS 885271-74-9)
- 6-Methoxychromane-3-carboxylic acid (CAS 182570-26-9)
- 6-Methoxychromane-4-carboxylic acid (CAS 405102-96-7)
- 7-Methoxychromane-2-carboxylic Acid (CAS 944899-78-9)
- 7-Methoxychromane-3-carbaldehyde (CAS 1083274-06-9)
- 8-Methoxychromane-3-carbaldehyde (CAS 1083317-40-1)
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