Orforglipron Impurity 42 CAS 2212021-92-4
| CAS No. | 2212021-92-4 |
| Molecular Formula | C20H27ClN4O2 |
| Molecular Weight | 390.91 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Orforglipron Impurity 42 (CAS 2212021-92-4, C20H27ClN4O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Orforglipron Impurity 42 (C20H27ClN4O2) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C20H27ClN4O2 |
| Molecular Weight | 390.91 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1998 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 4 |
Related Orforglipron Standards
- Orforglipron impurity 122 (CAS CATO-C4X-3234122)
- Orforglipron Impurity 88 (CAS CATO-C4X-323488)
- Orforglipron Impurity 19 (CAS CATO-C4X-323419)
- Orforglipron Impurity 4 (CAS 2212021-80-0)
- Orforglipron impurity 64 (CAS CATO-C4X-323464)
- Orforglipron impurity 128 (CAS CATO-C4X-3234128)
- Orforglipron impurity 131 (CAS CATO-C4X-3234131)
- Orforglipron Impurity 111 (CAS CATO-C4X-3234111)
Recommended Standards
- N-(4-(4-chlorophenyl)thiazol-2-yl)-2-((4-methoxyphenyl)thio)acetamide (CAS 338966-03-3)
- 4-(4-(Tert-butyl)phenyl)-2-((4-chlorobenzyl)thio)-4-oxobutanoic acid (CAS 303090-93-9)
- 6-[4-(3-Chlorophenyl)piperazin-1-yl]-3-cyclohexyl-1,2,3,4-tetrahydropyrimidine-2,4-dione (CAS 863588-32-3)
- 4,9-Dibromonaphtho[2,3-c][1,2,5]selenadiazole (CAS 364333-02-8)
- Remimazolam Impurity 15 (CAS CATO-C4X-282315)
- Desloratadine Impurity 63 (CAS CATO-C4X-143063)
- Metaraminol Impurity 40 (CAS 82499-20-5)
- Dolutegravir Impurity N1 (CAS 1335210-34-8)
- 4-((3-Methoxybenzyl)oxy)aniline (CAS 937607-42-6)
- 2,6-Dichloro-7-(3-(chloromethyl)benzyl)-7H-purine (CAS 924904-13-2)
- (E)-2-((5-chloro-2-methoxyphenyl)diazenyl)-1H-imidazole (CAS 77636-92-1)
- Ethyl 3,3-dimethylpent-4-enoate (CAS 7796-72-7)
- 6-Ethoxy-2-isopropyl-1H-pyrazolo[1,5-b][1,2,4]triazol-7-amine (CAS 227610-84-6)
- Semaglutide Impurity 143 (CAS CATO-C4X-2226143)
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