1-Bromo-2,4-difluoro-3-methoxybenzene CAS 221221-00-7
| CAS No. | 221221-00-7 |
| Molecular Formula | C7H5BrF2O |
| Molecular Weight | 223.01 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
1-Bromo-2,4-difluoro-3-methoxybenzene (CAS 221221-00-7) is a high-purity analytical reference standard with the molecular formula C7H5BrF2O and a molecular weight of 223.01 g/mol.
Owing to a hydroxyl group, an ether linkage, fluorine/bromine substitution, an aromatic ring system, 1-Bromo-2,4-difluoro-3-methoxybenzene is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 223.01 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
As a certified reference material (CRM), 1-Bromo-2,4-difluoro-3-methoxybenzene meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C7H5BrF2O |
| Molecular Weight | 223.01 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2020 |
| Halogen Content | F/Br-containing |
Related Bromo Standards
- 4-Bromo-2,6-difluoroanisole (CAS 104197-14-0)
- 2-Bromo-1,1,1,3-tetrafluoro-3-methylbutane (CAS 1099598-06-7)
- 3-Bromo-4,5-difluorobenzyl alcohol (CAS 1143502-71-9)
- (3-Bromo-2,5-difluorophenyl)methanol (CAS 1159186-56-7)
- 2-Bromo-1,4-difluoro-3-methoxybenzene (CAS 1208076-11-2)
- (2-Bromo-3,5-difluorophenyl)methanol (CAS 1256081-83-0)
- (4-Bromo-3,5-difluorophenyl)methanol (CAS 1256276-36-4)
- 3-Bromo-2-(difluoromethyl)phenol (CAS 1261477-43-3)
Recommended Standards
- (6-Bromo-2,3-difluorophenyl)methanol (CAS 651326-72-6)
- 1-Bromo-2,4-difluoro-5-methoxybenzene (CAS 943831-06-9)
- (5-Bromo-2,4-difluorophenyl)methanol (CAS 850213-59-1)
- 1-Bromo-2,5-difluoro-4-methoxybenzene (CAS 202865-60-9)
- Rhenium(I) pentacarbonyl chloride (CAS 14099-01-5)
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- Semaglutide Impurity 121 X Sodium Salt (CAS CATO-C4X-2226121)
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