2,4-Difluoro-3-methoxybenzoyl chloride CAS 221221-11-0
| CAS No. | 221221-11-0 |
| Molecular Formula | C8H5ClF2O2 |
| Molecular Weight | 206.57 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 206.57 g/mol gives 2,4-Difluoro-3-methoxybenzoyl chloride distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
2,4-Difluoro-3-methoxybenzoyl chloride (CAS 221221-11-0) is a high-purity analytical reference standard with the molecular formula C8H5ClF2O2 and a molecular weight of 206.57 g/mol.
Owing to a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system, 2,4-Difluoro-3-methoxybenzoyl chloride is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 206.57 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), 2,4-Difluoro-3-methoxybenzoyl chloride meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H5ClF2O2 |
| Molecular Weight | 206.57 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2020 |
| Halogen Content | F/Cl-containing |
Related Difluoro Standards
- 125369-56-4 2,6-Difluoro-4-methoxybenzoyl chloride DTXSID60381120 (CAS 125369-56-4)
- 3,6-Difluoro-2-methoxybenzoyl Chloride (CAS 1261825-37-9)
- 3,4-Difluoro-5-methoxybenzoyl chloride (CAS 1379371-54-6)
- 3,4-Difluoro-2-methoxybenzoyl chloride (CAS 1706461-08-6)
- 3,5-Difluoro-2-hydroxyphenacyl chloride (CAS 1706463-02-6)
- 2,3-Difluoro-4-methoxybenzoyl chloride (CAS 849632-69-5)
- 2,3-Difluoro-6-methoxybenzoyl chloride (CAS 886501-67-3)
- 2,5-Difluoro-4-methoxybenzoyl chloride (CAS 849632-70-8)
Recommended Standards
- 2,6-Difluoro-3-methoxybenzoyl chloride (CAS 886498-40-4)
- 2-(6-Chloro-2,3-difluorophenyl)acetic acid (CAS 887585-13-9)
- 2-Chloro-3-(difluoromethoxy)benzaldehyde (CAS 937069-63-1)
- 2-(4-Chlorophenyl)-2,2-difluoroacetic Acid (CAS 475301-73-6)
- N-Biotinyl-tryptamine, 97% (CAS 41994-03-0)
- 5-(3,4,5-Trifluorophenoxy)pentanenitrile (CAS 1443304-16-2)
- 5,8-Dihydroxy-1,4-dimethylquinolin-2(1H)-one (CAS 157463-87-1)
- 2-amino-4-phenylthiazole-5-carboxylic acid (CAS 228413-61-4)
- Milnacipran hydrochloride (CAS 101152-94-7)
- 4-(Difluoromethyl)-1H-indole-2-carboxylic acid (CAS 2167142-20-1)
- 2-((3,5-Dimethyl-2H-pyrrol-2-ylidene)methyl)-3,5-dimethyl-1H-pyrrole (CAS 2534-93-2)
- 7-Methyl-6-nitro-3H-imidazo[4,5-b]pyridine (CAS 1936193-86-0)
- 6-methyl-4-phenyl-1H,6H-[1,2]diazolo[3,4-c]pyrazol-3-amine (CAS 1311315-70-4)
- Insulin Glargine (CAS 160337-95-1)
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